دورية أكاديمية
Field Cancerization Therapies for the Management of Actinic Keratosis: An Updated Review.
العنوان: | Field Cancerization Therapies for the Management of Actinic Keratosis: An Updated Review. |
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المؤلفون: | Aggarwal I; Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA., Puyana C; Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA., Chandan N; Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA., Jetter N; Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA., Tsoukas M; Department of Dermatology, University of Illinois College of Medicine, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA. tsoukasm@uic.edu. |
المصدر: | American journal of clinical dermatology [Am J Clin Dermatol] 2024 May; Vol. 25 (3), pp. 391-405. Date of Electronic Publication: 2024 Feb 13. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 100895290 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1888 (Electronic) Linking ISSN: 11750561 NLM ISO Abbreviation: Am J Clin Dermatol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Auckland : Adis, Springer International Original Publication: Auckland ; Philadelphia : Adis International, c2000- |
مواضيع طبية MeSH: | Keratosis, Actinic*/therapy , Keratosis, Actinic*/drug therapy , Photochemotherapy*/methods , Photochemotherapy*/adverse effects , Skin Neoplasms*/prevention & control , Skin Neoplasms*/etiology , Skin Neoplasms*/therapy , Carcinoma, Squamous Cell*/prevention & control , Carcinoma, Squamous Cell*/etiology , Carcinoma, Squamous Cell*/therapy, Humans ; Cell Transformation, Neoplastic ; Administration, Cutaneous ; Treatment Outcome ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/adverse effects ; Photosensitizing Agents/therapeutic use ; Laser Therapy/methods |
مستخلص: | Field cancerization theory highlights that the skin surrounding actinic keratoses (AK) is also at increased risk for possible malignant transformation; thus, field-directed treatments may both reduce the risk of AK recurrence and potentially reduce the risk of development of cutaneous squamous cell carcinoma (cSCC). Photodynamic therapy (PDT) with either aminolevulinic acid (ALA) or methylaminolevulinate (MAL), as well as topical treatments such as 5-fluorouracil (5-FU), diclofenac gel, piroxicam, imiquimod, and ingenol mebutate, have all shown higher efficacy than vehicle treatments. PDT is widely recognized for its high efficacy; however, concerns for associated pain have driven new studies to begin using alternative illumination and pretreatment techniques, including lasers. Among topical treatments, a combination of 5-FU and salicylic acid (5-FU-SA) has shown to be the most effective but also causes the most adverse reactions. Tirbanibulin, a new topical agent approved for use in 2020, boasts a favorable safety profile in comparison with imiquimod, 5-FU, and diclofenac. Meanwhile, ingenol mebutate is no longer recommended for the treatment of AKs due to concerns for increased risk of cSCC development. Moving forward, an increasing number of studies push for standardization of outcome measures to better predict risk of future cSCC and use of more effective measures of cost to better guide patients. Here, we present an updated and comprehensive narrative review both confirming the efficacy of previously mentioned therapies as well as highlighting new approaches to PDT and discussing the use of lasers and novel topical treatments for treatment of AK. (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
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المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Photosensitizing Agents) |
تواريخ الأحداث: | Date Created: 20240213 Date Completed: 20240505 Latest Revision: 20240508 |
رمز التحديث: | 20240508 |
DOI: | 10.1007/s40257-023-00839-8 |
PMID: | 38351246 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1179-1888 |
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DOI: | 10.1007/s40257-023-00839-8 |