دورية أكاديمية
أعرض في EDS

Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.

التفاصيل البيبلوغرافية
العنوان: Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.
المؤلفون: Shook LL; Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Castro VM; Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Research Information Science and Computing, Mass General Brigham, Somerville, Massachusetts, USA., Herzberg EM; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Fourman LT; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Kaimal AJ; Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Perlis RH; Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Edlow AG; Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
المصدر: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 May; Vol. 32 (5), pp. 969-978. Date of Electronic Publication: 2024 Feb 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Malden, MA : John Wiley & Sons
Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006-
مواضيع طبية MeSH: COVID-19*/epidemiology , SARS-CoV-2* , Prenatal Exposure Delayed Effects* , Pregnancy Complications, Infectious*/virology , Pregnancy Complications, Infectious*/epidemiology, Humans ; Female ; Pregnancy ; Retrospective Studies ; Infant ; Adult ; Male ; Massachusetts/epidemiology ; Infant, Newborn ; Body Mass Index ; Cardiometabolic Risk Factors ; Child Development ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology
مستخلص: Objective: The objective of this study is to determine whether in utero exposure to SARS-CoV-2 is associated with increased risk for a cardiometabolic diagnosis by 18 months of age.
Methods: This retrospective electronic health record (EHR)-based cohort study included the live-born offspring of all individuals who delivered during the COVID-19 pandemic (April 1, 2020-December 31, 2021) at eight hospitals in Massachusetts. Offspring exposure was defined as a positive maternal SARS-CoV-2 polymerase chain reaction test during pregnancy. The primary outcome was presence of an ICD-10 code for a cardiometabolic disorder in offspring EHR by 18 months. Weight-, length-, and BMI-for-age z scores were calculated and compared at 6-month intervals from birth to 18 months.
Results: A total of 29,510 offspring (1599 exposed and 27,911 unexposed) were included. By 18 months, 6.7% of exposed and 4.4% of unexposed offspring had received a cardiometabolic diagnosis (crude odds ratio [OR] 1.47 [95% CI: 1.10 to 1.94], p = 0.007; adjusted OR 1.38 [1.06 to 1.77], p = 0.01). Exposed offspring had a significantly greater mean BMI-for-age z score versus unexposed offspring at 6 months (z score difference 0.19 [95% CI: 0.10 to 0.29], p < 0.001; adjusted difference 0.04 [-0.06 to 0.13], p = 0.4).
Conclusions: Exposure to maternal SARS-CoV-2 infection was associated with an increased risk of receiving a cardiometabolic diagnosis by 18 months preceded by greater BMI-for-age at 6 months.
(© 2024 The Obesity Society.)
References: Am J Obstet Gynecol. 2008 Nov;199(5):498.e1-7. (PMID: 18448080)
JAMA Netw Open. 2019 Apr 5;2(4):e192843. (PMID: 31026028)
Pediatrics. 2004 Nov;114(5):1362-4. (PMID: 15520122)
Obstet Gynecol. 2020 Aug;136(2):300-302. (PMID: 32496337)
Alcohol Clin Exp Res. 2014 Sep;38(9):2502-8. (PMID: 25159809)
Am J Obstet Gynecol. 2018 Feb;218(2S):S869-S879. (PMID: 29422215)
Pediatrics. 2016 May;137(5):. (PMID: 27244803)
J Matern Fetal Neonatal Med. 2022 Dec;35(25):8412-8418. (PMID: 34542385)
Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R1-R12. (PMID: 25924881)
J Clin Endocrinol Metab. 2007 Jan;92(1):98-103. (PMID: 17032722)
JAMA Netw Open. 2022 Jun 1;5(6):e2215787. (PMID: 35679048)
Sci Transl Med. 2021 Oct 27;13(617):eabi7428. (PMID: 34664987)
J Clin Endocrinol Metab. 2023 Sep 18;108(10):2579-2588. (PMID: 36988326)
MMWR Morb Mortal Wkly Rep. 2020 Nov 06;69(44):1641-1647. (PMID: 33151921)
Ann Epidemiol. 2018 Sep;28(9):619-624.e1. (PMID: 30017226)
Pediatrics. 2003 Mar;111(3):e221-6. (PMID: 12612275)
JAMA Netw Open. 2018 Sep 7;1(5):e182460. (PMID: 30646168)
Am J Clin Nutr. 2009 Nov;90(5):1303-13. (PMID: 19759171)
Matern Child Health J. 2012 Jan;16(1):125-32. (PMID: 21327952)
Prenat Diagn. 2020 Aug;40(9):1109-1125. (PMID: 32643194)
Lancet. 2013 Aug 10;382(9891):525-34. (PMID: 23541370)
BMC Pediatr. 2003 Dec 16;3:13. (PMID: 14678563)
Ultrasound Obstet Gynecol. 2021 Apr;57(4):573-581. (PMID: 33620113)
Mol Psychiatry. 2015 Jun;20(6):727-34. (PMID: 25155880)
J Pediatr. 2021 Nov;238:208-214.e2. (PMID: 34302856)
Arch Pathol Lab Med. 2022 Jun 1;146(6):660-676. (PMID: 35142798)
Mol Metab. 2018 Sep;15:8-19. (PMID: 29773464)
Mol Aspects Med. 2022 Oct;87:101095. (PMID: 35450725)
Sci Rep. 2022 Jan 18;12(1):942. (PMID: 35042979)
Front Physiol. 2022 Mar 10;13:787617. (PMID: 35360231)
J Immunol. 2022 Oct 15;209(8):1465-1473. (PMID: 36192115)
Pediatrics. 2016 Jul;138(1):. (PMID: 27343232)
BMC Infect Dis. 2020 Jul 11;20(1):502. (PMID: 32652939)
Int J Pediatr Obes. 2010 Dec;5(6):458-60. (PMID: 20233144)
MMWR Morb Mortal Wkly Rep. 2020 Nov 06;69(44):1635-1640. (PMID: 33151917)
Int J Obes (Lond). 2020 Apr;44(4):771-780. (PMID: 31804609)
Ann Epidemiol. 2013 Jun;23(6):307-13. (PMID: 23622955)
Pediatrics. 2016 Oct;138(4):. (PMID: 27590899)
J Acquir Immune Defic Syndr. 2020 Feb 1;83(2):126-134. (PMID: 31738195)
Sci Rep. 2019 Aug 8;9(1):11528. (PMID: 31395930)
JAMA Netw Open. 2023 Mar 1;6(3):e234415. (PMID: 36951861)
iScience. 2022 May 20;25(5):104223. (PMID: 35434541)
Cell Mol Life Sci. 2020 Dec;77(23):4861-4898. (PMID: 32494846)
Lancet Digit Health. 2022 Feb;4(2):e95-e104. (PMID: 35034863)
J Clin Endocrinol Metab. 2013 Feb;98(2):794-801. (PMID: 23284005)
معلومات مُعتمدة: U19 AI167899 United States AI NIAID NIH HHS; RF1MH132336 United States MH NIMH NIH HHS; U54 MH118919 United States MH NIMH NIH HHS; K23 HD100266 United States HD NICHD NIH HHS; K12 HD103096 United States HD NICHD NIH HHS; R01MH116270 United States MH NIMH NIH HHS; RF1 MH132336 United States MH NIMH NIH HHS; R01 HD100022 United States HD NICHD NIH HHS; U54MH118919 United States MH NIMH NIH HHS; R01 MH116270 United States MH NIMH NIH HHS; P30 DK040561 United States DK NIDDK NIH HHS
تواريخ الأحداث: Date Created: 20240214 Date Completed: 20240424 Latest Revision: 20240827
رمز التحديث: 20240827
مُعرف محوري في PubMed: PMC11039385
DOI: 10.1002/oby.23998
PMID: 38351665
قاعدة البيانات: MEDLINE
الوصف
تدمد:1930-739X
DOI:10.1002/oby.23998