Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease Using 18 F-Sodium Fluoride Positron Emission Tomography Imaging.

التفاصيل البيبلوغرافية
العنوان:	Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease Using ¹⁸ F-Sodium Fluoride Positron Emission Tomography Imaging.
المؤلفون:	Chou TH; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Nabavinia M; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Tram NK; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Rimmerman ET; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH.; Biophysics Graduate Program Ohio State University Columbus OH., Patel S; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Musini KN; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Eisert SN; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Wolfe T; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Wynveen MK; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Matsuzaki Y; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Kitsuka T; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Iwaki R; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Janse SA; Center for Biostatistics Ohio State University Columbus OH., Bobbey AJ; Department of Radiology Nationwide Children's Hospital Columbus OH., Breuer CK; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Goodchild L; Animal Resources Core Research Institute at Nationwide Children's Hospital Columbus OH., Malbrue R; Animal Resources Core Research Institute at Nationwide Children's Hospital Columbus OH., Shinoka T; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH., Atway SA; Department of Orthopaedics Ohio State University College of Medicine Columbus OH., Go MR; Division of Vascular Diseases & Surgery, Department of Surgery Ohio State University College of Medicine Columbus OH., Stacy MR; Center for Regenerative Medicine Research Institute at Nationwide Children's Hospital Columbus OH.; Biophysics Graduate Program Ohio State University Columbus OH.; Division of Vascular Diseases & Surgery, Department of Surgery Ohio State University College of Medicine Columbus OH.
المصدر:	Journal of the American Heart Association [J Am Heart Assoc] 2024 Feb 20; Vol. 13 (4), pp. e031823. Date of Electronic Publication: 2024 Feb 14.
نوع المنشور:	Clinical Trial; Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH:	Muscle, Skeletal/diagnostic imaging , Peripheral Arterial Disease/diagnostic imaging, Animals ; Humans ; Perfusion ; Positron-Emission Tomography/methods ; Sodium Fluoride ; Swine
مستخلص:	Background: Perfusion deficits contribute to symptom severity, morbidity, and death in peripheral artery disease (PAD); however, no standard method for quantifying absolute measures of skeletal muscle perfusion exists. This study sought to preclinically test and clinically translate a positron emission tomography (PET) imaging approach using an atherosclerosis-targeted radionuclide, fluorine-18-sodium fluoride ( ¹⁸ F-NaF), to quantify absolute perfusion in PAD. Methods and Results: Eight Yorkshire pigs underwent unilateral femoral artery ligation and dynamic ¹⁸ F-NaF PET/computed tomography imaging on the day of and 2 weeks after occlusion. Following 2-week imaging, calf muscles were harvested to quantify microvascular density. PET methodology was validated with microspheres in 4 additional pig studies and translated to patients with PAD (n=39) to quantify differences in calf perfusion across clinical symptoms/stages and perfusion responses in a case of revascularization. Associations between PET perfusion, ankle-brachial index, toe-brachial index, and toe pressure were assessed in relation to symptoms. ¹⁸ F-NaF PET/computed tomography quantified significant deficits in calf perfusion in pigs following arterial occlusion and perfusion recovery 2 weeks after occlusion that coincided with increased muscle microvascular density. Additional studies confirmed that PET-derived perfusion measures agreed with microsphere-derived perfusion measures. Translation of imaging methods demonstrated significant decreases in calf perfusion with increasing severity of PAD and quantified perfusion responses to revascularization. Perfusion measures were also significantly associated with symptom severity, whereas traditional hemodynamic measures were not. Conclusions: ¹⁸ F-NaF PET imaging quantifies perfusion deficits that correspond to clinical stages of PAD and represents a novel perfusion imaging strategy that could be partnered with atherosclerosis-targeted ¹⁸ F-NaF PET imaging using a single radioisotope injection. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03622359.
References:	Physiol Rep. 2016 Aug;4(16):. (PMID: 27535483) JACC Cardiovasc Imaging. 2012 Dec;5(12):1224-30. (PMID: 23236972) J Appl Physiol (1985). 2002 Apr;92(4):1709-16. (PMID: 11896041) J Nucl Med. 2001 Jul;42(7):1091-100. (PMID: 11438633) Vascular. 2023 Oct;31(5):961-967. (PMID: 35580351) J Nucl Med. 1997 Jan;38(1):93-8. (PMID: 8998159) EJNMMI Res. 2023 Jan 17;13(1):3. (PMID: 36648583) JACC Cardiovasc Imaging. 2021 Aug;14(8):1614-1624. (PMID: 33221224) JACC Cardiovasc Imaging. 2008 May;1(3):343-50. (PMID: 19356447) Diagnostics (Basel). 2020 May 16;10(5):. (PMID: 32429406) Circ Cardiovasc Imaging. 2018 May;11(5):e006932. (PMID: 29748311) J Physiol. 2020 Sep;598(18):3793-3801. (PMID: 32666574) Circulation. 2019 Sep 17;140(12):e657-e672. (PMID: 31401843) Circulation. 2021 Aug 31;144(9):e171-e191. (PMID: 34315230) J Magn Reson Imaging. 2018 Jun;47(6):1578-1588. (PMID: 29193492) Am J Phys Med Rehabil. 2010 Jun;89(6):473-86. (PMID: 20357647) J Nucl Med. 2010 Dec;51(12):1826-9. (PMID: 21078790) Sci Rep. 2020 Apr 14;10(1):6342. (PMID: 32286372) Arch Plast Surg. 2012 May;39(3):227-31. (PMID: 22783531) EClinicalMedicine. 2022 Jul 01;50:101532. (PMID: 35812995) Front Med (Lausanne). 2022 Jan 12;8:793975. (PMID: 35096884) J Nucl Med. 2003 Jun;44(6):915-9. (PMID: 12791819) J Nucl Med. 1997 Dec;38(12):1970-6. (PMID: 9430479) Eur J Radiol. 2013 Apr;82(4):640-6. (PMID: 23265181) Eur Radiol. 2021 Aug;31(8):5507-5513. (PMID: 33547479) J Vasc Surg. 2019 Feb;69(2):555-562. (PMID: 30292608) J Nucl Cardiol. 2020 Dec;27(6):1923-1933. (PMID: 31939039) Nucl Med Commun. 2011 Sep;32(9):808-17. (PMID: 21799369) J Vasc Surg. 1997 Sep;26(3):517-38. (PMID: 9308598) Eur J Nucl Med Mol Imaging. 2002 Jul;29(7):907-14. (PMID: 12111131) Adv Wound Care (New Rochelle). 2020 Mar 1;9(3):103-110. (PMID: 31993252) Circulation. 2021 Apr 27;143(17):e875-e891. (PMID: 33761757) J Cardiovasc Magn Reson. 2015 Feb 22;17:23. (PMID: 25890198) Vasa. 2019 Aug;48(5):419-424. (PMID: 31063045) Circ Cardiovasc Imaging. 2014 Jan;7(1):92-9. (PMID: 24170237)
معلومات مُعتمدة:	R01 HL135103 United States HL NHLBI NIH HHS
فهرسة مساهمة:	Keywords: fluorine‐18‐sodium fluoride; limb ischemia; perfusion imaging; peripheral artery disease; positron emission tomography; skeletal muscle
سلسلة جزيئية:	ClinicalTrials.gov NCT03622359
المشرفين على المادة:	8ZYQ1474W7 (Sodium Fluoride)
تواريخ الأحداث:	Date Created: 20240214 Date Completed: 20240221 Latest Revision: 20240425
رمز التحديث:	20240425
مُعرف محوري في PubMed:	PMC11010069
DOI:	10.1161/JAHA.123.031823
PMID:	38353265
قاعدة البيانات:	MEDLINE

View record at Wiley

Full Text Finder

الوصف
تدمد:	2047-9980
DOI:	10.1161/JAHA.123.031823