دورية أكاديمية
أعرض في EDS

Association of an In-Hospital Desirability of Outcomes Ranking Scale With Postdischarge Health-Related Quality of Life: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation.

التفاصيل البيبلوغرافية
العنوان: Association of an In-Hospital Desirability of Outcomes Ranking Scale With Postdischarge Health-Related Quality of Life: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation.
المؤلفون: Logan GE; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO., Banks RK; Department of Pediatrics, University of Utah, Salt Lake City, UT., Reeder R; Department of Pediatrics, University of Utah, Salt Lake City, UT., Miller K; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO., Mourani PM; Department of Pediatrics, Section of Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR., Bennett TD; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO., Bourque SL; Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO., Meert KL; Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI., Zimmerman J; Department of Pediatrics, Seattle Children's Hospital, Seattle Research Institute, University of Washington School of Medicine, Seattle, WA., Maddux AB; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
المصدر: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2024 Jun 01; Vol. 25 (6), pp. 528-537. Date of Electronic Publication: 2024 Feb 14.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Lippincott Williams & Wilkins, c2000-
مواضيع طبية MeSH: Quality of Life* , Intensive Care Units, Pediatric*, Humans ; Child ; Child, Preschool ; Female ; Male ; Adolescent ; Prospective Studies ; Infant ; Shock, Septic/therapy ; Shock, Septic/mortality ; Patient Discharge ; Outcome Assessment, Health Care/methods
مستخلص: Objectives: To develop a desirability of outcome ranking (DOOR) scale for use in children with septic shock and determine its correlation with a decrease in 3-month postadmission health-related quality of life (HRQL) or death.
Design: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study.
Setting: Twelve U.S. PICUs, 2013-2017.
Patients: Children (1 mo-18 yr) with septic shock.
Interventions: None.
Measurements and Main Results: We applied a 7-point pediatric critical care (PCC) DOOR scale: 7: death; 6: extracorporeal life support; 5: supported by life-sustaining therapies (continuous renal replacement therapy, vasoactive, or invasive ventilation); 4: hospitalized with or 3: without organ dysfunction; 2: discharged with or 1: without new morbidity to patients by assigning the highest applicable score on specific days post-PICU admission. We analyzed Spearman rank-order correlations (95% CIs) between proximal outcomes (PCC-DOOR scale on days 7, 14, and 21, ventilator-free days, cumulative 28-day Pediatric Logistic Organ Dysfunction-2 (PELOD-2) scores, and PICU-free days) and 3-month decrease in HRQL or death. HRQL was measured by Pediatric Quality of Life Inventory 4.0 or Functional Status II-R for patients with developmental delay. Patients who died were assigned the worst possible HRQL score. PCC-DOOR scores were applied to 385 patients, median age 6 years (interquartile range 2, 13) and 177 (46%) with a complex chronic condition(s). Three-month outcomes were available for 245 patients (64%) and 42 patients (17%) died. PCC-DOOR scale on days 7, 14, and 21 demonstrated fair correlation with the primary outcome (-0.42 [-0.52, -0.31], -0.47 [-0.56, -0.36], and -0.52 [-0.61, -0.42]), similar to the correlations for cumulative 28-day PELOD-2 scores (-0.51 [-0.59, -0.41]), ventilator-free days (0.43 [0.32, 0.53]), and PICU-free days (0.46 [0.35, 0.55]).
Conclusions: The PCC-DOOR scale is a feasible, practical outcome for pediatric sepsis trials and demonstrates fair correlation with decrease in HRQL or death at 3 months.
Competing Interests: Dr. Logan’s institution received funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (K23HD096018) (R01HD073362 and cooperative agreements U10-HD050012, U10-HD050096, U10-HD063108, U10-HD049983 U10-HD049981, U10-HD063114, and U10-HD063106). Drs. Logan, Banks, Reeder, Meert, Zimmerman, and Maddux received support for article research from the National Institutes of Health (NIH). Drs. Banks, Bennett, and Zimmerman’s institutions received funding from the NICHD. Dr. Banks disclosed government work. Drs. Reeder and Meert’s institutions received funding from the NIH. Dr. Bennett’s institution received funding from the National Center for Advancing Translational Sciences and the National Heart, Lung, and Blood Institute. Dr. Zimmerman’s institution received funding from Immunexpress; he received funding from Elsevier Publishing. Dr. Maddux’s institution received funding from the NICHD (K23 HD096018) and the Francis Family Foundation. The remaining authors have disclosed that they do not have any potential conflicts of interest.
(Copyright © 2024 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
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معلومات مُعتمدة: U10 HD063108 United States HD NICHD NIH HHS; U10 HD050012 United States HD NICHD NIH HHS; K23 HD096018 United States HD NICHD NIH HHS; U10 HD049981 United States HD NICHD NIH HHS; U10 HD050096 United States HD NICHD NIH HHS; U10 HD063106 United States HD NICHD NIH HHS; K24 HL168225 United States HL NHLBI NIH HHS; R01 HD073362 United States HD NICHD NIH HHS; U10 HD063114 United States HD NICHD NIH HHS
تواريخ الأحداث: Date Created: 20240214 Date Completed: 20240605 Latest Revision: 20240718
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11153013
DOI: 10.1097/PCC.0000000000003470
PMID: 38353586
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-7535
DOI:10.1097/PCC.0000000000003470