دورية أكاديمية
Mast Cell Activation Syndrome and Gut Dysfunction: Diagnosis and Management.
| العنوان: | Mast Cell Activation Syndrome and Gut Dysfunction: Diagnosis and Management. |
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| المؤلفون: | Hamilton MJ; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mjhamilton@bwh.harvard.edu. |
| المصدر: | Current gastroenterology reports [Curr Gastroenterol Rep] 2024 Apr; Vol. 26 (4), pp. 107-114. Date of Electronic Publication: 2024 Feb 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Current Science Inc Country of Publication: United States NLM ID: 100888896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-312X (Electronic) Linking ISSN: 15228037 NLM ISO Abbreviation: Curr Gastroenterol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Current Science Inc., c1999- |
| مواضيع طبية MeSH: | Mastocytosis*/complications , Mastocytosis*/diagnosis , Mastocytosis*/therapy , Mast Cell Activation Syndrome* , Irritable Bowel Syndrome*/complications , Irritable Bowel Syndrome*/diagnosis , Irritable Bowel Syndrome*/therapy , Gastrointestinal Diseases*/diagnosis , Gastrointestinal Diseases*/etiology , Gastrointestinal Diseases*/therapy, Humans ; Mast Cells/pathology |
| مستخلص: | Purpose of Review: Mast cell activation syndrome (MCAS) is a clinical disorder that may explain irritable bowel syndrome (IBS) type symptoms as well as other allergic symptoms experienced by an individual. The diagnosis and treatment of MCAS with specific focus on gastrointestinal (GI) manifestations is reviewed. Recent Findings: Although biomarkers for MCAS remain elusive, testing for baseline serum tryptase will distinguish the type of mast cell disorder and urine tests for mast cell mediator metabolites may support the diagnosis. Endoscopy and Colonoscopy with biopsies is not used to diagnose MCAS but is important to rule out other conditions that may cause symptoms. There is increased awareness of the association between MCAS and autonomic dysfunction, small fiber neuropathy, and connective tissue disorders which all impact GI symptoms. MCAS is a disorder often of unknown etiology (idiopathic) and characterized by intermittent allergy type symptoms that affect multiple organ systems after exposure to a trigger. GI symptoms including abdominal cramping and loose stool are prominent and mimic those of IBS. Diagnostic testing is performed to assess for elevations in mast cell mediators during symptoms and to rule out other conditions. A comprehensive treatment plan includes medications that target mast cells, treatments for associated conditions including autonomic dysfunction, and management of comorbid psychiatric illness and nutritional deficits. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| فهرسة مساهمة: | Keywords: Autonomic dysfunction; Gastrointestinal; Histamine; Mast cell activation; Neuropathy; Tryptase |
| تواريخ الأحداث: | Date Created: 20240214 Date Completed: 20240325 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| DOI: | 10.1007/s11894-024-00924-w |
| PMID: | 38353900 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1534-312X |
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| DOI: | 10.1007/s11894-024-00924-w |