دورية أكاديمية
أعرض في EDS

Tumour-infiltrated cortex participates in large-scale cognitive circuits.

التفاصيل البيبلوغرافية
العنوان: Tumour-infiltrated cortex participates in large-scale cognitive circuits.
المؤلفون: Mandal AS; Brain-Gene Development Lab, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, USA; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK. Electronic address: Ayan.Mandal@pennmedicine.upenn.edu., Wiener C; Faculty of Engineering, Bar-Ilan University, Ramat-Gan, Israel., Assem M; Medical Research Council, Cognition and Brain Sciences Unit, University of Cambridge, UK., Romero-Garcia R; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK; Department of Medical Physiology and Biophysics, Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Sevilla, Spain., Coelho P; Neurophys Limited, UK., McDonald A; Department of Neuropsychology, Cambridge University Hospitals NHS Foundation Trust, UK., Woodberry E; Department of Neuropsychology, Cambridge University Hospitals NHS Foundation Trust, UK., Morris RC; Department of Neuropsychology, Cambridge University Hospitals NHS Foundation Trust, UK., Price SJ; Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, UK., Duncan J; Medical Research Council, Cognition and Brain Sciences Unit, University of Cambridge, UK; Department of Experimental Psychology, University of Oxford, UK., Santarius T; Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, UK; Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, UK., Suckling J; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK; Cambridge and Peterborough NHS Foundation Trust, UK., Hart MG; St George's, University of London & St George's University Hospitals NHS Foundation Trust, Institute of Molecular and Clinical Sciences, Neurosciences Research Centre, Cranmer Terrace, London, UK., Erez Y; Faculty of Engineering, Bar-Ilan University, Ramat-Gan, Israel; Medical Research Council, Cognition and Brain Sciences Unit, University of Cambridge, UK; Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel. Electronic address: yaara.erez@biu.ac.ul.
المصدر: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2024 Apr; Vol. 173, pp. 1-15. Date of Electronic Publication: 2024 Jan 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Masson Country of Publication: Italy NLM ID: 0100725 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1973-8102 (Electronic) Linking ISSN: 00109452 NLM ISO Abbreviation: Cortex Subsets: MEDLINE
أسماء مطبوعة: Publication: Milan : Masson
Original Publication: Varese.
مواضيع طبية MeSH: Brain*/physiology , Glioma*/diagnostic imaging, Humans ; Executive Function/physiology ; Cognition/physiology ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods ; Neural Pathways/physiology
مستخلص: The extent to which tumour-infiltrated brain tissue contributes to cognitive function remains unclear. We tested the hypothesis that cortical tissue infiltrated by diffuse gliomas participates in large-scale cognitive circuits using a unique combination of intracranial electrocorticography (ECoG) and resting-state functional magnetic resonance (fMRI) imaging in four patients. We also assessed the relationship between functional connectivity with tumour-infiltrated tissue and long-term cognitive outcomes in a larger, overlapping cohort of 17 patients. We observed significant task-related high gamma (70-250 Hz) power modulations in tumour-infiltrated cortex in response to increased cognitive effort (i.e., switch counting compared to simple counting), implying preserved functionality of neoplastic tissue for complex tasks probing executive function. We found that tumour locations corresponding to task-responsive electrodes exhibited functional connectivity patterns that significantly co-localised with canonical brain networks implicated in executive function. Specifically, we discovered that tumour-infiltrated cortex with larger task-related high gamma power modulations tended to be more functionally connected to the dorsal attention network (DAN). Finally, we demonstrated that tumour-DAN connectivity is evident across a larger cohort of patients with gliomas and that it relates to long-term postsurgical outcomes in goal-directed attention. Overall, this study contributes convergent fMRI-ECoG evidence that tumour-infiltrated cortex participates in large-scale neurocognitive circuits that support executive function in health. These findings underscore the potential clinical utility of mapping large-scale connectivity of tumour-infiltrated tissue in the care of patients with diffuse gliomas.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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فهرسة مساهمة: Keywords: Brain tumour; Electrocorticography (ECOG); Executive function; Functional connectivity; Glioma; Neural circuits; fMRI
تواريخ الأحداث: Date Created: 20240214 Date Completed: 20240327 Latest Revision: 20240522
رمز التحديث: 20240522
مُعرف محوري في PubMed: PMC10988771
DOI: 10.1016/j.cortex.2024.01.004
PMID: 38354669
قاعدة البيانات: MEDLINE
الوصف
تدمد:1973-8102
DOI:10.1016/j.cortex.2024.01.004