دورية أكاديمية
Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non-muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics.
| العنوان: | Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non-muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics. |
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| المؤلفون: | Subiela JD; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain. Electronic address: jdsubiela@gmail.com., Krajewski W; Department of Minimally Invasive Robotic Urology, Center of Excellence in Urology, Wrocław Medical University, Wrocław, Poland., González-Padilla DA; Department of Urology, Clínica Universidad de Navarra, Madrid, Spain., Laszkiewicz J; Department of Minimally Invasive Robotic Urology, Center of Excellence in Urology, Wrocław Medical University, Wrocław, Poland., Taborda J; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Aumatell J; Servicio de Urología, Hospital Universitario Rey Juan Carlos, Universidad Rey Juan Carlos Móstoles, Madrid, Spain., Sanchez Encinas M; Servicio de Urología, Hospital Universitario Rey Juan Carlos, Universidad Rey Juan Carlos Móstoles, Madrid, Spain., Basile G; Division of Experimental Oncology, Department of Urology, Urological Research Institute, Vita-Salute San Raffaele University, Milan, Italy., Moschini M; Division of Experimental Oncology, Department of Urology, Urological Research Institute, Vita-Salute San Raffaele University, Milan, Italy., Caño-Velasco J; Department of Urology, Hospital Universitario Gregorio Marañon, Madrid, Spain., Lopez Perez E; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Del Olmo Durán P; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Gallioli A; Department of Urology, Fundaciò Puigvert, Autonomous University of Barcelona, Barcelona, Spain., Tukiendorf A; Institute of Health Sciences, Opole University, Opole, Poland; University Clinical Hospital in Opole, Opole, Poland., D'Andrea D; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Yuen-Chun Teoh J; S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region., Serna Céspedes A; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Pichler R; Medical University of Innsbruck, Department of Urology, Comprehensive Cancer Center Innsbruck (CCCI), Innsbruck, Austria., Afferi L; Department of Urology, Luzerner Kantonsspital, Lucerne, Switzerland., Del Giudice F; Department of Maternal-Infant and Urological Sciences, Policlinico Umberto I Hospital, 'Sapienza' University of Rome, Rome, Italy., Gomez Rivas J; Department of Urology, Hospital Clínico San Carlos, Madrid, Spain., Albisinni S; Urology Unit, Department of Surgical Sciences, Tor Vergata University Hospital, University of Rome Tor Vergata, Rome, Italy., Soria F; Division of Urology, Department of Surgical Sciences Molinette Hospital University of Torino School of Medicine, Torino, Italy., Ploussard G; Department of Urology, La Croix du Sud Hospital, Quint Fonsegrives, France., Mertens LS; Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Rajwa P; Department of Urology, Medical University of Silesia, Zabrze, Poland., Laukhtina E; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia., Pradere B; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, La Croix du Sud Hospital, Quint Fonsegrives, France., Tully K; Department of Urology and Neurourology, Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany., Guerrero-Ramos F; Department of Urology, Hospital Universitario 12 de Octubre, Madrid, Spain; ROC Clinic, Madrid, Spain; Department of Urology, Hospital Universitario HM Sanchinarro, Madrid, Spain., Rodríguez-Faba Ó; Department of Urology, Fundaciò Puigvert, Autonomous University of Barcelona, Barcelona, Spain., Alvarez-Maestro M; Department of Urology, Hospital Universitario La Paz, Madrid, Spain., Dominguez-Escrig JL; Department of Urology, Fundación Instituto Valenciano de Oncología, Valencia, Spain., Szydełko T; Department of Minimally Invasive Robotic Urology, Center of Excellence in Urology, Wrocław Medical University, Wrocław, Poland., Gomez Dos Santos V; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Jiménez Cidre MÁ; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain., Burgos Revilla FJ; Department of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain. |
| مؤلفون مشاركون: | European Association of Urology-Young Academic Urologists EAU-YAU: Urothelial Carcinoma Working Group |
| المصدر: | European urology oncology [Eur Urol Oncol] 2024 Feb 13. Date of Electronic Publication: 2024 Feb 13. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101724904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2588-9311 (Electronic) Linking ISSN: 25889311 NLM ISO Abbreviation: Eur Urol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2018]- |
| مستخلص: | Background: The European Association of Urology (EAU) recommends discussing upfront radical cystectomy for all patients with very high risk (VHR) non-muscle-invasive bladder carcinoma (NMIBC), but the role of bacillus Calmette-Guérin (BCG) treatment remains controversial. Objective: To analyze oncological outcomes in VHR NMIBC patients (EAU risk groups) treated with adequate BCG. Design, Setting, and Participants: A multi-institutional retrospective study involving patients with VHR NMIBC who received adequate BCG therapy from 2007 to 2020 was conducted. Outcome Measurements and Statistical Analysis: A survival analysis estimated recurrence-free survival (RFS), progression-free survival (PFS), and the cumulative incidence of cancer-specific mortality (CSM) after accounting for other causes of mortality as competing risk events and of the overall mortality (OM). Conditional survival probabilities for 0-4 yr without events were computed. Cox regression assessed the predictors of oncological outcomes. Results and Limitation: A total of 640 patients, with a median 47 (32-67) mo follow-up for event-free individuals, were analyzed. High-grade RFS and PFS at 5 yr were 53% (49-57%) and 78% (74-82%), respectively. The cumulative incidence of CSM and OM at 5 yr was 13% (10-16%) and 16% (13-19%), respectively. Conditional RFS, PFS, overall survival, and cancer-specific survival at 4 yr were 91%, 96%, 87%, and 94%, respectively. Cox regression identified tumor grade (hazard ratio [HR]: 1.54; 1.1-2) and size (HR: 1.3; 1.1-1.7) as RFS predictors. Tumor multiplicity predicted RFS (HR: 1.6; 1.3-2), PFS (HR: 2; 1.2-3.3), and CSM (HR: 2; 1.2-3.2), while age predicted OM (HR: 1.48; 1.1-2). Conclusions: Patients with VHR NMIBC who receive adequate BCG therapy have a more favorable prognosis than predicted by EAU risk groups, especially among those with a sustained response, in whom continuing maintenance therapy emerges as a viable alternative to radical cystectomy. Patient Summary: Our research shows that a sustained response to bacillus Calmette-Guérin in patients can lead to favorable outcomes, serving as a viable alternative to cystectomy for select cases. (Copyright © 2024 European Association of Urology. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bacillus Calmette-Guérin; Non–muscle-invasive bladder carcinoma; Very high risk |
| تواريخ الأحداث: | Date Created: 20240214 Latest Revision: 20240408 |
| رمز التحديث: | 20240408 |
| DOI: | 10.1016/j.euo.2024.01.017 |
| PMID: | 38355375 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2588-9311 |
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| DOI: | 10.1016/j.euo.2024.01.017 |