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Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids.

التفاصيل البيبلوغرافية
العنوان: Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids.
المؤلفون: Suvannapruk W; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Fisher LE; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Luckett JC; School of Life Sciences, Faculty of Medicine and Health Science, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Edney MK; Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Kotowska AM; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Kim DH; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Scurr DJ; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Ghaemmaghami AM; Immunology & Immuno-bioengineering Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK., Alexander MR; Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park Nottingham, Nottingham, NG7 2RD, UK.
المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Apr; Vol. 11 (15), pp. e2306000. Date of Electronic Publication: 2024 Feb 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : WILEY-VCH, [2014]-
مواضيع طبية MeSH: Foreign-Body Reaction* , Biocompatible Materials*/chemistry, Mice ; Animals ; Polymers ; Anti-Inflammatory Agents ; Lipids
مستخلص: A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in the modulation of the host immune response and are the cells responsible for persistent inflammatory reactions to implanted biomaterials. Two novel immune-instructive polymers that stimulate pro- or anti-inflammatory responses from macrophages in vitro are investigated. These also modulate in vivo foreign body responses (FBR) when implanted subcutaneously in mice. Immunofluorescent staining of tissue abutting the polymer reveals responses consistent with pro- or anti-inflammatory responses previously described for these polymers. Three Dimensional OrbiTrap Secondary Ion Mass Spectrometry (3D OrbiSIMS) analysis to spatially characterize the metabolites in the tissue surrounding the implant, providing molecular histology insight into the metabolite response in the host is applied. For the pro-inflammatory polymer, monoacylglycerols (MG) and diacylglycerols (DG) are observed at increased intensity, while for the anti-inflammatory coating, the number of phospholipid species detected decreased, and pyridine and pyrimidine levels are elevated. Small molecule signatures from single-cell studies of M2 macrophages in vitro correlate with the in vivo observations, suggesting potential for prediction. Metabolite characterization by the 3D OrbiSIMS is shown to provide insight into the mechanism of bio-instructive materials as medical devices and to inform on the FBR to biomaterials.
(© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
References: Annu Rev Anal Chem (Palo Alto Calif). 2020 Jun 12;13(1):249-271. (PMID: 32212820)
Cell Death Differ. 2018 Mar;25(4):767-783. (PMID: 29230001)
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17253-8. (PMID: 24101477)
Mol Biol Cell. 2004 Jun;15(6):2932-42. (PMID: 15064353)
Adv Mater. 2023 May;35(21):e2205709. (PMID: 36871193)
Adv Drug Deliv Rev. 2019 Apr;144:148-161. (PMID: 31491445)
Anal Chem. 2016 Jul 5;88(13):6758-66. (PMID: 27228471)
Mol Cell Biochem. 2000 Jan;203(1-2):127-33. (PMID: 10724341)
Nat Methods. 2021 Dec;18(12):1452-1456. (PMID: 34862499)
Biomaterials. 2011 Oct;32(28):6692-709. (PMID: 21715002)
Curr Opin Biotechnol. 2022 Apr;74:194-203. (PMID: 34959210)
Nat Biomed Eng. 2023 Nov;7(11):1419-1436. (PMID: 37749310)
Anal Chem. 2022 Jul 5;94(26):9389-9398. (PMID: 35713879)
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):324-334. (PMID: 29217509)
Nat Immunol. 2009 Jun;10(6):627-35. (PMID: 19430478)
Infect Immun. 2001 Dec;69(12):7711-7. (PMID: 11705952)
Anal Chem. 2011 May 1;83(9):3239-43. (PMID: 21456522)
Metabolites. 2021 Jun 08;11(6):. (PMID: 34201055)
Science. 2002 Jul 12;297(5579):240-3. (PMID: 12114623)
Am J Clin Nutr. 2002 Jun;75(6):1005-11. (PMID: 12036806)
Mass Spectrom Rev. 2022 Sep;41(5):662-694. (PMID: 33433028)
F1000Prime Rep. 2014 Mar 03;6:13. (PMID: 24669294)
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. (PMID: 18216768)
Front Immunol. 2018 Jan 29;9:38. (PMID: 29434586)
Nat Methods. 2017 Dec;14(12):1175-1183. (PMID: 29131162)
Biochim Biophys Acta. 2014 Apr;1837(4):470-80. (PMID: 24051056)
J Biol Chem. 2014 Jan 31;289(5):3001-12. (PMID: 24337578)
Nat Rev Immunol. 2008 Dec;8(12):958-69. (PMID: 19029990)
Nat Mater. 2017 Jun;16(6):671-680. (PMID: 28319612)
J Immunol. 1999 Feb 15;162(4):2266-74. (PMID: 9973503)
Metabolites. 2021 Apr 14;11(4):. (PMID: 33919944)
Mol Biomed. 2022 Jan 26;3(1):5. (PMID: 35079944)
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2114380119. (PMID: 35298332)
J Ovarian Res. 2022 Aug 13;15(1):93. (PMID: 35964092)
Nat Commun. 2020 Nov 17;11(1):5832. (PMID: 33203841)
Sci Adv. 2021 Apr 2;7(14):. (PMID: 33811079)
Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000588. (PMID: 27148576)
ACS Appl Mater Interfaces. 2020 Nov 11;12(45):51026-51035. (PMID: 33121243)
Front Physiol. 2017 Aug 23;8:600. (PMID: 28878685)
J Immunol. 2013 Jul 15;191(2):773-84. (PMID: 23749634)
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3857-61. (PMID: 8171002)
Nat Methods. 2021 Jul;18(7):799-805. (PMID: 34226721)
Anal Chem. 2020 Jul 7;92(13):9008-9015. (PMID: 32460495)
Biotechniques. 2011 Oct;51(4):239-40, 242, 244 passim. (PMID: 21988690)
Science. 2020 Apr 17;368(6488):283-290. (PMID: 32299949)
Biomaterials. 1984 Jan;5(1):5-10. (PMID: 6375747)
Anal Chem. 2009 Feb 1;81(3):1040-8. (PMID: 19125566)
J Immunol. 2008 Sep 15;181(6):3733-9. (PMID: 18768823)
J Immunol Methods. 2012 Jan 31;375(1-2):196-206. (PMID: 22075274)
Nat Mater. 2018 Dec;17(12):1134-1144. (PMID: 30349032)
Adv Sci (Weinh). 2024 Apr;11(15):e2306000. (PMID: 38356246)
J Leukoc Biol. 2015 Dec;98(6):953-62. (PMID: 26168797)
Eur J Med Chem. 2009 Nov;44(11):4547-56. (PMID: 19616348)
Anal Chem. 2021 May 11;93(18):6947-6954. (PMID: 33900724)
معلومات مُعتمدة: The Royal Thai Government Scholarship provided by the National Metal and Materials Technology Center (MTEC), the National Science and Technology Development Agency (NSTDA), Thailand; EP/P029868/1 Engineering and Physical Sciences Research Council; EP/N006615/1 Engineering and Physical Sciences Research Council
فهرسة مساهمة: Keywords: 3D OrbiSIMS; Macrophage; immune‐instructive polymers and metabolomics
المشرفين على المادة: 0 (Biocompatible Materials)
0 (Polymers)
0 (Anti-Inflammatory Agents)
0 (Lipids)
تواريخ الأحداث: Date Created: 20240215 Date Completed: 20240418 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11022720
DOI: 10.1002/advs.202306000
PMID: 38356246
قاعدة البيانات: MEDLINE
الوصف
تدمد:2198-3844
DOI:10.1002/advs.202306000