دورية أكاديمية
Bayesian evaluation of temporal changes in sensitivity and specificity of three serological tests for multiple circulating strains of rabbit haemorrhagic disease virus.
| العنوان: | Bayesian evaluation of temporal changes in sensitivity and specificity of three serological tests for multiple circulating strains of rabbit haemorrhagic disease virus. |
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| المؤلفون: | Patel KK; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia 5371, Australia; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, South Australia, 5064, Australia; Centre for Invasive Species Solutions, Bruce, Australian Capital Territory 2617, Australia. Electronic address: kandarp.patel@adelaide.edu.au., Toft N; IQinAbox, Værløse, Denmark; Toft Analytics, Copenhagen, Denmark., Kovaliski J; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, South Australia, 5064, Australia; Centre for Invasive Species Solutions, Bruce, Australian Capital Territory 2617, Australia., Page B; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, South Australia, 5064, Australia; Centre for Invasive Species Solutions, Bruce, Australian Capital Territory 2617, Australia., Appuhamilage RMJJE; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, South Australia, 5064, Australia; Centre for Invasive Species Solutions, Bruce, Australian Capital Territory 2617, Australia., Taggart PL; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia 5371, Australia; Centre for Invasive Species Solutions, Bruce, Australian Capital Territory 2617, Australia; Vertebrate Pest Research Unit, Department of Primary Industries NSW, Queanbeyan, New South Wales 2620, Australia; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia; Bush Heritage Australia, Melbourne, Victoria 3000, Australia. |
| المصدر: | Preventive veterinary medicine [Prev Vet Med] 2024 Apr; Vol. 225, pp. 106137. Date of Electronic Publication: 2024 Feb 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishing Country of Publication: Netherlands NLM ID: 8217463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1716 (Electronic) Linking ISSN: 01675877 NLM ISO Abbreviation: Prev Vet Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Scientific Publishing Original Publication: Amsterdam, Netherlands : Elsevier, [1982- |
| مواضيع طبية MeSH: | Hemorrhagic Disease Virus, Rabbit* , Caliciviridae Infections*/diagnosis , Caliciviridae Infections*/epidemiology , Caliciviridae Infections*/veterinary, Animals ; Rabbits ; Bayes Theorem ; Australia/epidemiology ; Immunoglobulin G ; Sensitivity and Specificity ; Serologic Tests/veterinary |
| مستخلص: | Competition and indirect ELISAs are currently being used to monitor rabbit haemorrhagic disease viruses (RHDV1 and RHDV2) in rabbits worldwide. Temporal changes in the sensitivity (Se) and specificity (Sp) of RHDV1 competition-ELISA (cELISA1), RHDV2 competition-ELISA (cELISA2), and RHDV1 Immunoglobulin G (IgG1) ELISA, were investigated using Bayesian Latent Class models (BCLM) in the Australian wild rabbit population where both viruses circulate simultaneously and a long-term serological dataset exists. When cELISA1 was compared to IgG1 ELISA, the Se of cELISA1 improved while the Sp of IgG1 ELISA declined over the 2011-21. This corresponded with a decline in the true RHDV1 prevalence in 2018-21, suggesting that a large proportion of RHDV1 exposed rabbits survived the introduction and dominance of RHDV2 up to approximately 2017/2018, after which they died and were not replaced. The Se and Sp estimates for 2014-15 for both cELISA1 and IgG1 ELISA, and the true prevalence when analysing all three tests together were similar to those obtained from the analysis of cELISA1/IgG1 ELISA. The same was also true for the Se and Sp of cELISA2 and IgG1 ELISA estimates from 2018 onwards. This suggests that RHDV1 was the dominant infection type in 2014-15, but RHDV2 was the dominant infection type in 2018-21. Further, the increase in Se of cELISA2 and the low Sp of IgG1 ELISA in the cELISA2/IgG1 ELISA analysis, compared to the Se of cELISA2 and Sp of IgG1 ELISA when analysing all three tests together suggests that the underlying infection status was more influenced by RHDV2 and that the higher Se of IgG1 ELISA is due to cross-reaction of RHDV2 antibodies on IgG1 ELISA. The true prevalence data suggest that RHDV2 exposure peaked in 2017. Our findings show that test characteristics changed in response to the changing virus prevalences over time. IgG1 ELISA, currently having a high Se, should be used to monitor both viruses and will perform better than both cELISAs. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest in this study. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bayesian latent class; Diagnostic sensitivity and specificity; ELISA; Pest management; Rabbit haemorrhagic disease virus |
| المشرفين على المادة: | 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20240215 Date Completed: 20240315 Latest Revision: 20240315 |
| رمز التحديث: | 20240315 |
| DOI: | 10.1016/j.prevetmed.2024.106137 |
| PMID: | 38359470 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-1716 |
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| DOI: | 10.1016/j.prevetmed.2024.106137 |