دورية أكاديمية
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases.
العنوان: | Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. |
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المؤلفون: | Loh JS; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia., Mak WQ; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia., Tan LKS; School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, 1, Jalan Taylors, Subang Jaya, 47500, Selangor, Malaysia.; Digital Health & Medical Advancements, Taylor's University, 1, Jalan Taylors, Subang Jaya, 47500, Selangor, Malaysia., Ng CX; School of Biosciences, Faculty of Health & Medical Sciences, Taylor's University, 1, Jalan Taylors, Subang Jaya, 47500, Selangor, Malaysia., Chan HH; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia., Yeow SH; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK., Foo JB; School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, 1, Jalan Taylors, Subang Jaya, 47500, Selangor, Malaysia.; Digital Health & Medical Advancements, Taylor's University, 1, Jalan Taylors, Subang Jaya, 47500, Selangor, Malaysia., Ong YS; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia., How CW; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia. how.cheewun@monash.edu., Khaw KY; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia. Khaw.KooiYeong@monash.edu. |
المصدر: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Feb 16; Vol. 9 (1), pp. 37. Date of Electronic Publication: 2024 Feb 16. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group, [2016]- |
مواضيع طبية MeSH: | Neurodegenerative Diseases*/therapy , Neurodegenerative Diseases*/metabolism , Probiotics*/therapeutic use, Humans ; Brain/metabolism ; Brain-Gut Axis ; Prebiotics |
مستخلص: | The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development, aging, and disease. The advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome-host interactions. Evidence has unveiled the bidirectional communication between the gut microbiome and the central nervous system, referred to as the "microbiota-gut-brain axis". The microbiota-gut-brain axis represents an important regulator of glial functions, making it an actionable target to ameliorate the development and progression of neurodegenerative diseases. In this review, we discuss the mechanisms of the microbiota-gut-brain axis in neurodegenerative diseases. As the gut microbiome provides essential cues to microglia, astrocytes, and oligodendrocytes, we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative diseases. Subsequently, we discuss the mechanisms of the microbiota-gut-brain axis in neurodegenerative diseases using a metabolite-centric approach, while also examining the role of gut microbiota-related neurotransmitters and gut hormones. Next, we examine the potential of targeting the intestinal barrier, blood-brain barrier, meninges, and peripheral immune system to counteract glial dysfunction in neurodegeneration. Finally, we conclude by assessing the pre-clinical and clinical evidence of probiotics, prebiotics, and fecal microbiota transplantation in neurodegenerative diseases. A thorough comprehension of the microbiota-gut-brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases. (© 2024. The Author(s).) |
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المشرفين على المادة: | 0 (Prebiotics) |
تواريخ الأحداث: | Date Created: 20240215 Date Completed: 20240219 Latest Revision: 20240219 |
رمز التحديث: | 20240219 |
مُعرف محوري في PubMed: | PMC10869798 |
DOI: | 10.1038/s41392-024-01743-1 |
PMID: | 38360862 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2059-3635 |
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DOI: | 10.1038/s41392-024-01743-1 |