دورية أكاديمية
أعرض في EDS

Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection.

التفاصيل البيبلوغرافية
العنوان: Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection.
المؤلفون: Graham JB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Swarts JL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bell TA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hock P; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Farrington J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shaw GD; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lund JM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.
المصدر: IScience [iScience] 2024 Feb 02; Vol. 27 (3), pp. 109103. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address the role of host genetics on immune phenotypes and clinical outcomes following viral infection by studying genetically diverse mice from the Collaborative Cross (CC), allowing for use of a small animal model with controlled genetic diversity while maintaining genetic replicates. We demonstrate variation by deeply profiling a broad range of innate and adaptive immune cell phenotypes at steady-state in 63 genetically distinct CC mouse strains and link baseline immune signatures with virologic and clinical disease outcomes following infection of mice with herpes simplex virus 2 (HSV-2) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This work serves as a resource for CC strain selection based on steady-state immune phenotypes or disease presentation upon viral infection, and further, points to possible pre-infection immune correlates of survival and early viral clearance upon infection.
Competing Interests: S.R.L. and R.S.B. are listed on a patent for the SARS-CoV-2 MA10 virus (US 11225508 B1, “Mouse-adapted SARS-CoV-2 viruses and methods of use thereof”). Funding for this study was provided by NIH grant U19 AI100625 (to R.S.B.), R01 AI157253 (to R.S.B.), P01 AI132130 (to M.T.F. and F.P.M.d.V.), and R21 AI152559 (to J.M.L.).
(© 2024 The Author(s).)
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فهرسة مساهمة: Keywords: Immunology; Virology
تواريخ الأحداث: Date Created: 20240216 Latest Revision: 20240217
رمز التحديث: 20240217
مُعرف محوري في PubMed: PMC10867580
DOI: 10.1016/j.isci.2024.109103
PMID: 38361611
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2024.109103