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Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicated rats.

التفاصيل البيبلوغرافية
العنوان: Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicated rats.
المؤلفون: Zeweil MM; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Khafaga AF; Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt., Mahmoud SF; Department of Cytology and Histology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Wasef L; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Saleh H; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Elrehim AMA; Department of Physiology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Bassuoni NF; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt., Alwaili MA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Saeedi NH; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Ghoneim HA; Department of Physiology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
المصدر: Frontiers in pharmacology [Front Pharmacol] 2024 Feb 01; Vol. 15, pp. 1348145. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Media]
مستخلص: Introduction: 7,12-dimethylbenz (a) anthracene (DMBA) is a harmful polycyclic aromatic hydrocarbon derivative known for its cytotoxic, carcinogenic, and mutagenic effects in mammals and other species. Annona muricata, L. (Graviola; GRV) is a tropical fruit tree traditionally well-documented for its various medicinal benefits. This investigation is the first report on the potential antioxidant and antinfammatory reno-protective impact of GRV against DMBA-induced nephrotoxicity in rats. Methods: Forty male albino rats were allocated into four equal groups (n = 10). The 1st group served as the control, the 2nd group (GRV) was gastro-gavaged with GRV (200 mg/kg b.wt), the 3rd group (DMBA) was treated with a single dose of DMBA (15 mg/kg body weight), and the 4th group (DMBA + GRV) was gastro-gavaged with a single dose of DMBA, followed by GRV (200 mg/kg b.wt). The GRV administration was continued for 8 weeks. Results and Discussion: Results revealed a significant improvement in renal function, represented by a decrease in urea, creatinine, and uric acid (UA) in the DMBA + GRV group. The antioxidant potential of GRV was confirmed in the DMBA + GRV group by a significant decline in malondialdehyde (MDA) and a significant increase in catalase (CAT), superoxide dismutase (SOD), glutathione S transferase (GST), and reduced glutathione (GSH) compared to DMBA-intoxicated rats; however, it was not identical to the control. Additionally, the antiinflammatory role of GRV was suggested by a significant decline in mRNA expression of cytochrome P450, family 2, subfamily e, polypeptide 1 (CYP2E1), tumor necrosis factor-alpha (TNF-α), and interleukin 1 beta (IL-1β) in the DMBA + GRV group. Moreover, GRV improved the histopathologic and immunohistochemical expression of TNF-α, CYP450, and IL1β in DMBA-intoxicated kidney tissue. Conclusively, GRV is a natural medicinal product that can alleviate the renal injury resulting from environmental exposure to DMBA. The reno-protective effects of GRV may involve its anti-inflammatory and/or antioxidant properties, which are based on the presence of phytochemical compounds such as acetogenins, alkaloids, and flavonoids.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Zeweil, Khafaga, Mahmoud, Wasef, Saleh, Elrehim, Bassuoni, Alwaili, Saeedi and Ghoneim.)
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فهرسة مساهمة: Keywords: CYP2E1; DMBA; IL-1β; MDA; TNF-α; antioxidant enzymes; graviola; nephrotoxicity
تواريخ الأحداث: Date Created: 20240216 Latest Revision: 20240217
رمز التحديث: 20240217
مُعرف محوري في PubMed: PMC10867119
DOI: 10.3389/fphar.2024.1348145
PMID: 38362149
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-9812
DOI:10.3389/fphar.2024.1348145