دورية أكاديمية
Morphological characteristics of the foveal avascular zone in pathological myopia and its relationship with macular structure and microcirculation.
| العنوان: | Morphological characteristics of the foveal avascular zone in pathological myopia and its relationship with macular structure and microcirculation. |
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| المؤلفون: | Sui J; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China., Li H; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China., Bai Y; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China., He Q; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China., Sun Z; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China., Wei R; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China. rwei@tmu.edu.cn.; Tianjin Binhai High-Tech Industrial Development Zone, No. 251 Fukang Road, Huayuan Industrial Zone (Nankai District), Tianjin, China. rwei@tmu.edu.cn. |
| المصدر: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Jul; Vol. 262 (7), pp. 2121-2133. Date of Electronic Publication: 2024 Feb 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c1982- |
| مواضيع طبية MeSH: | Tomography, Optical Coherence*/methods , Microcirculation*/physiology , Myopia, Degenerative*/physiopathology , Myopia, Degenerative*/diagnosis , Fluorescein Angiography*/methods , Retinal Vessels*/pathology , Retinal Vessels*/diagnostic imaging , Retinal Vessels*/physiopathology , Fovea Centralis*/blood supply , Fovea Centralis*/pathology , Fundus Oculi*, Humans ; Male ; Cross-Sectional Studies ; Female ; Adult ; Middle Aged ; Visual Acuity ; Retrospective Studies ; Macula Lutea/blood supply ; Macula Lutea/pathology ; Choroid/blood supply ; Choroid/pathology |
| مستخلص: | Purpose: To explore the characteristics of macular structure, microcirculation, and foveal avascular zone (FAZ) morphology in pathological myopia and to research the associations between these factors and pathological myopia. Methods: This is a cross-sectional study. The study included 103 eyes with non-high myopia and 206 eyes with high myopia (139 with simple high myopia and 67 with pathological myopia). Macular structural and microcirculation parameters were determined using optical coherence tomography angiography (OCTA). The FAZ morphological parameters were measured manually using Image J software. Correlations between pathological myopia and various factors were analyzed. Results: Patients with pathological myopia had a thinner retinal thickness (RT) and choroidal thickness (CT) and a lower retinal superficial vascular density (SVD), retinal deep vascular complex density (DVD), choriocapillaris perfusion area (CCPA), and choroidal vascularity index (CVI) (all P < 0.05). Patients with pathological myopia had a larger FAZ area, perimeter, major axis, minor axis, acircularity index (AI), and lower circularity index (CI) (all P < 0.01). The axial length (AL), the major axis of the superficial FAZ, CI, and AI were significantly correlated with myopia severity (all P < 0.05). Conclusions: Patients with pathological myopia exhibited worse macular microcirculation and thinner macular retina and choroid. The FAZ in pathological myopia was larger and more irregular. The AL, CI, and AI were significantly associated with myopia severity. Thus, CI and AI might serve as new indicators for monitoring the progression of myopia. Further investigations should be performed. Trial Registration: Clinical Trials.gov Identifier: ChiCTR2100046590. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | 82070929 National Natural Science Foundation of China; TJYXZDXK-037A Tianjin Key Medical Discipline (Specialty) Construction Project |
| فهرسة مساهمة: | Keywords: Circularity index; Macular structures; Microcirculation; OCTA; Pathological myopia; foveal avascular zone |
| تواريخ الأحداث: | Date Created: 20240217 Date Completed: 20240703 Latest Revision: 20240718 |
| رمز التحديث: | 20240718 |
| DOI: | 10.1007/s00417-024-06403-2 |
| PMID: | 38367069 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1435-702X |
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| DOI: | 10.1007/s00417-024-06403-2 |