دورية أكاديمية
أعرض في EDS

Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice.

التفاصيل البيبلوغرافية
العنوان: Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice.
المؤلفون: Yun YR; World Institute of Kimchi, Nam-Gu, Gwangju 61755, Republic of Korea. Electronic address: yunyerang@wikim.re.kr., Lee JE; World Institute of Kimchi, Nam-Gu, Gwangju 61755, Republic of Korea.
المصدر: Nutrition research (New York, N.Y.) [Nutr Res] 2024 Apr; Vol. 124, pp. 43-54. Date of Electronic Publication: 2024 Jan 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004- > : Tarrytown, NY : Elsevier Science
Original Publication: New York : Pergamon Press, c1981-
مواضيع طبية MeSH: Endoplasmic Reticulum Stress*/drug effects , Mice, Inbred C57BL* , Triglycerides*/blood , Triglycerides*/metabolism , Liver*/metabolism , Liver*/drug effects , Fermented Foods* , Benzenesulfonamides* , Fluorocarbons*, Aminoimidazole Carboxamide/*analogs & derivatives, Animals ; Humans ; Hep G2 Cells ; Male ; Mice ; Aminoimidazole Carboxamide/pharmacology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/prevention & control ; Non-alcoholic Fatty Liver Disease/etiology ; Sulfonamides/pharmacology ; Ribonucleotides/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Lipid Metabolism/drug effects ; Cell Survival/drug effects ; Liver X Receptors/metabolism ; Tunicamycin/pharmacology ; Lipogenesis/drug effects ; Fatty Liver/drug therapy ; Fatty Liver/prevention & control
مستخلص: Kimchi is a traditional fermented food that contains abundant nutrients and functional ingredients with various health benefits. We previously reported that kimchi active components suppress hepatic steatosis caused by endoplasmic reticulum (ER) stress in vitro and in vivo. Therefore, we assessed the effect of kimchi on the inhibition of hepatic steatosis caused by ER stress in HepG2 cells and C57BL/6N mice to verify the hypothesis that kimchi may potentially inhibit nonalcoholic fatty liver disease. We investigated the effect of kimchi on cell viability and triglyceride concentrations in cells and on lipid profile, lipid accumulation, and expression of related genes in cells and mice with hepatic steatosis. A mechanistic study was also performed using the liver X receptor α agonist T0901317 and the AMP-activated protein kinase agonist AICAR. Kimchi was noncytotoxic and effectively reduced triglyceride concentrations and suppressed hepatic steatosis-related gene expression in cells and mice. Additionally, kimchi recovered weight loss, lowered the serum and liver tissue lipid profiles, suppressed lipid accumulation, and reduced the effects of T0901317 and AICAR on lipogenic gene expression in tunicamycin-treated mice. Our results highlight that kimchi could prevent hepatic steatosis caused by ER stress in cells and mice.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: AMP-activated protein kinase; Endoplasmic reticulum stress; Kimchi; Liver X receptor α; Nonalcoholic fatty liver disease; Tunicamycin
المشرفين على المادة: 0 (Triglycerides)
360-97-4 (Aminoimidazole Carboxamide)
0 (T0901317)
0 (Sulfonamides)
0 (Ribonucleotides)
F0X88YW0YK (AICA ribonucleotide)
EC 2.7.11.31 (AMP-Activated Protein Kinases)
0 (Liver X Receptors)
11089-65-9 (Tunicamycin)
0 (Benzenesulfonamides)
0 (Fluorocarbons)
تواريخ الأحداث: Date Created: 20240217 Date Completed: 20240501 Latest Revision: 20240501
رمز التحديث: 20240502
DOI: 10.1016/j.nutres.2024.01.013
PMID: 38367426
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0739
DOI:10.1016/j.nutres.2024.01.013