دورية أكاديمية
أعرض في EDS

Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study.
المؤلفون: Oboth R; Department of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda. Electronic address: obabdurazak@gmail.com., Kamabu LK; Department of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda., Lekuya HM; Department of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda., Bbosa GS; Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Makerere University Kampala, Uganda., Sajatovic M; Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA., Katabira E; Department of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Uganda., Kaddumukasa M; Department of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Uganda., Galukande M; Department of Surgery, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda.
المصدر: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Mar; Vol. 152, pp. 109693. Date of Electronic Publication: 2024 Feb 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Diego, CA : Academic Press, c2000-
مواضيع طبية MeSH: Skull Fracture, Depressed*/complications , Epilepsy, Post-Traumatic*/complications , Brain Injuries, Traumatic*/complications, Adult ; Humans ; Male ; Female ; Cross-Sectional Studies ; Risk Factors ; Hospitals
مستخلص: Introduction: Post-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care.
Objective: To determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH).
Methods: A cross-sectional study was conducted among 333 study participants between March 2021 and February 2022. Socio-demographic, clinical laboratory factors and anti-seizure medications were collected using a study questionnaire. Data was analysed to determine the prevalence of PTS and factors associated with occurrence of PTS among patients with DSF.
Results: The mean age (±SD) of study participants was 31.2, (±10.5) years, with a male to female ratio of 10.4:1. Nearly half of the study participants had attained secondary level of education, while 31.6 % (105) were peasants (subsistence farmers). The overall prevalence of PTS among DSF study participants was 16.2 % (54participants). Late presentation of PTS was the highest at 9.0 % (30) followed by early PTS at 3.9 % [13] and immediate PTS at 3.3 % [11]. Moderate Glasgow coma score (GCS: 9-13), p < 0.015, severe traumatic brain injury (GCS: 3-8), p < 0.026 at the time of admission and midline brain shift (≥5mm), p < 0.009 were associated with PTS. Phenytoin (94.3 %) was the most commonly used ASM followed by phenobarbitone (1.4 %) and Valproate (1.1 %) among study participants.
Conclusion: Patients with moderate and severe traumatic brain injury and midline brain shift were associated with post traumatic seizures. Early identification and intervention may reduce the burden of posttraumatic seizures in this category of patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
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معلومات مُعتمدة: D43 NS118560 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Anti-seizures medicines; Depressed skull fractures; Post-traumatic seizures
تواريخ الأحداث: Date Created: 20240218 Date Completed: 20240305 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC11027507
DOI: 10.1016/j.yebeh.2024.109693
PMID: 38368722
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-5069
DOI:10.1016/j.yebeh.2024.109693