دورية أكاديمية
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying.
| العنوان: | Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying. |
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| المؤلفون: | Oyama S; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University., Ogawa N; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University., Kawai K; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University., Iwai K; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University., Yasunaga T; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University., Yamamoto H; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University. |
| المصدر: | Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2024; Vol. 72 (2), pp. 190-199. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN: 1347-5223 (Electronic) Linking ISSN: 00092363 NLM ISO Abbreviation: Chem Pharm Bull (Tokyo) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo, Pharmaceutical Society of Japan. |
| مواضيع طبية MeSH: | Probucol*/chemistry , Water*/chemistry, Atorvastatin ; Drug Stability ; Crystallography, X-Ray ; X-Ray Diffraction ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Calorimetry, Differential Scanning |
| مستخلص: | A co-amorphous model drug was prepared by the spray-drying (SD) of probucol (PC) and atorvastatin calcium trihydrate salt (ATO) as low water solubility and co-former components, respectively. The physicochemical properties of the prepared samples were characterized by powder X-ray diffraction (PXRD) analysis, thermal analysis, Fourier transform infrared spectroscopy (FTIR), and dissolution tests. Stability tests were also conducted under a stress environment of 40 °C and 75% relative humidity. The results of PXRD measurements and thermal analysis suggested that PC and ATO form a co-amorphous system by SD. Thermal analysis also indicated an endothermic peak that followed an exotherm in amorphous PC and a physical mixture (PM) of amorphous PC and ATO; however, no endothermic peak was detected in the co-amorphous system. The dissolution profiles for PC in the co-amorphous sample composed of PC and ATO were improved compared to those for raw PC crystals or the PM. Stability tests indicated that the co-amorphous material formed by PC and ATO can be stored for 35 d without crystallization, whereas amorphous PC became crystallized within a day. Therefore, co-amorphization of PC and ATO prepared by SD is considered to be a useful method to improve the solubility of PC in water. |
| فهرسة مساهمة: | Keywords: atorvastatin calcium trihydrate salt; co-amorphous; dissolution test; probucol; spray-drying; stability test |
| المشرفين على المادة: | A0JWA85V8F (Atorvastatin) P3CTH044XJ (Probucol) 059QF0KO0R (Water) |
| تواريخ الأحداث: | Date Created: 20240218 Date Completed: 20240220 Latest Revision: 20240220 |
| رمز التحديث: | 20240220 |
| DOI: | 10.1248/cpb.c23-00673 |
| PMID: | 38369345 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-5223 |
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| DOI: | 10.1248/cpb.c23-00673 |