دورية أكاديمية
Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study.
العنوان: | Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study. |
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المؤلفون: | Harvey NT; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.; School of Medicine, University of Western Australia, Perth, WA, Australia., Palmer DJ; School of Medicine, University of Western Australia, Perth, WA, Australia.; Telethon Kids Institute, University of Western Australia, Perth, WA, Australia., Tucker P; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia., Chakera A; Renal Medicine and Transplantation, Sir Charles Gairdner Hospital, Perth, WA, Australia., Foster R; Dermatology, Sir Charles Gairdner Hospital, Perth, WA, Australia., Lim W; Renal Medicine and Transplantation, Sir Charles Gairdner Hospital, Perth, WA, Australia., Trevithick RW; Department of Health, Western Australian Cancer Registry, Perth, WA, Australia., Wood BA; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia. |
المصدر: | JAAD international [JAAD Int] 2023 Dec 29; Vol. 15, pp. 51-58. Date of Electronic Publication: 2023 Dec 29 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101774762 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3287 (Electronic) Linking ISSN: 26663287 NLM ISO Abbreviation: JAAD Int Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] : Elsevier Inc., [2020]- |
مستخلص: | Background: Cutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases. Objectives: To determine the histological parameters which have independent prognostic value for cutaneous squamous cell carcinoma arising in renal transplant recipients. Methods: Case-control study incorporating a retrospective blinded histological review of 70 archived specimens of cutaneous squamous cell carcinoma diagnosed in renal transplant recipients, comprising 10 cases where the tumor had progressed and 60 controls. Results: Progression was significantly associated with head and neck location, size, depth, poor histological grade, perineural invasion (including small caliber perineural invasion), lymphovascular invasion, and a desmoplastic growth pattern. Limitations: The retrospective nature and the low number of cases compared to controls. Conclusion: In immunosuppressed patients both small caliber perineural invasion and a desmoplastic growth pattern may also have prognostic significance in addition to other histological parameters already recognized in formal staging schemes. Competing Interests: None disclosed. (© 2024 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.) |
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فهرسة مساهمة: | Keywords: carcinoma; logistic models; retrospective studies; skin neoplasms; squamous cell; transplant recipients |
تواريخ الأحداث: | Date Created: 20240219 Latest Revision: 20240220 |
رمز التحديث: | 20240220 |
مُعرف محوري في PubMed: | PMC10869928 |
DOI: | 10.1016/j.jdin.2023.11.010 |
PMID: | 38371661 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2666-3287 |
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DOI: | 10.1016/j.jdin.2023.11.010 |