دورية أكاديمية
أعرض في EDS

Evolved changes in phenotype across skeletal muscles in deer mice native to high altitude.

التفاصيل البيبلوغرافية
العنوان: Evolved changes in phenotype across skeletal muscles in deer mice native to high altitude.
المؤلفون: Garrett EJ; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Prasad SK; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Schweizer RM; Division of Biological Sciences, University of Montana, Missoula, Montana, United States.; United States Department of Agriculture, Agricultural Research Service, Pollinating Insects Research Unit, Utah State University, Logan, Utah, United States., McClelland GB; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Scott GR; Department of Biology, McMaster University, Hamilton, Ontario, Canada.
المصدر: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2024 Apr 01; Vol. 326 (4), pp. R297-R310. Date of Electronic Publication: 2024 Feb 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bethesda, Md. : American Physiological Society
مواضيع طبية MeSH: Altitude* , Peromyscus*/physiology, Animals ; Hypoxia/metabolism ; Muscle, Skeletal/metabolism ; Acclimatization ; Phenotype
مستخلص: The cold and hypoxic conditions at high altitude necessitate high metabolic O 2 demands to support thermogenesis while hypoxia reduces O 2 availability. Skeletal muscles play key roles in thermogenesis, but our appreciation of muscle plasticity and adaptation at high altitude has been hindered by past emphasis on only a small number of muscles. We examined this issue in deer mice ( Peromyscus maniculatus ). Mice derived from both high-altitude and low-altitude populations were born and raised in captivity and then acclimated as adults to normoxia or hypobaric hypoxia (12 kPa O 2 for 6-8 wk). Maximal activities of citrate synthase (CS), cytochrome c oxidase (COX), β-hydroxyacyl-CoA dehydrogenase (HOAD), hexokinase (HK), pyruvate kinase (PK), and lactate dehydrogenase (LDH) were measured in 20 muscles involved in shivering, locomotion, body posture, ventilation, and mastication. Principal components analysis revealed an overall difference in muscle phenotype between populations but no effect of hypoxia acclimation. High-altitude mice had greater activities of mitochondrial enzymes and/or lower activities of PK or LDH across many (but not all) respiratory, limb, core and mastication muscles compared with low-altitude mice. In contrast, chronic hypoxia had very few effects across muscles. Further examination of CS in the gastrocnemius showed that population differences in enzyme activity stemmed from differences in protein abundance and mRNA expression but not from population differences in CS amino acid sequence. Overall, our results suggest that evolved increases in oxidative capacity across many skeletal muscles, at least partially driven by differences in transcriptional regulation, may contribute to high-altitude adaptation in deer mice. NEW & NOTEWORTHY Most previous studies of muscle plasticity and adaptation in high-altitude environments have focused on a very limited number of skeletal muscles. Comparing high-altitude versus low-altitude populations of deer mice, we show that a large number of muscles involved in shivering, locomotion, body posture, ventilation, and mastication exhibit greater mitochondrial enzyme activities in the high-altitude population. Therefore, evolved increases in mitochondrial oxidative capacity across skeletal muscles contribute to high-altitude adaptation.
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معلومات مُعتمدة: RGPIN-2018-05707 Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN-462246-2014 Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
فهرسة مساهمة: Keywords: acclimatization; evolutionary physiology; high elevation; muscle metabolism; shivering thermogenesis
تواريخ الأحداث: Date Created: 20240219 Date Completed: 20240319 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11283899
DOI: 10.1152/ajpregu.00206.2023
PMID: 38372126
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-1490
DOI:10.1152/ajpregu.00206.2023