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Vitamin D3 mitigates type 2 diabetes induced by a high carbohydrate-high fat diet in rats: Role of the purinergic system.

التفاصيل البيبلوغرافية
العنوان: Vitamin D3 mitigates type 2 diabetes induced by a high carbohydrate-high fat diet in rats: Role of the purinergic system.
المؤلفون: Vera Castro MF; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil. Electronic address: mifave_11@hotmail.com., Assmann CE; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Reichert KP; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Coppetti PM; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Stefanello N; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., da Silva AD; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Mostardeiro VB; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., de Jesus LB; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., da Silveira MV; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Schirmann AA; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Fracasso M; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Maciel RM; Department of Pathology, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Morsch VMM; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil., Schetinger MRC; Graduate Program in Biological Sciences, Toxicological Biochemistry, Center for Natural and Exact Sciences, Federal University of Santa Maria, University Campus, Santa Maria, RS, Brazil. Electronic address: mariachitolina@gmail.com.
المصدر: The Journal of nutritional biochemistry [J Nutr Biochem] 2024 May; Vol. 127, pp. 109602. Date of Electronic Publication: 2024 Feb 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: <1996->: New York, NY : Elsevier Science
Original Publication: Stoneham, MA, USA : Butterworths, c1990-
مواضيع طبية MeSH: Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Insulins*, Rats ; Male ; Animals ; Rats, Wistar ; Cholecalciferol/pharmacology ; Diet, High-Fat/adverse effects ; Vitamins ; Adenosine Monophosphate/metabolism ; Adenosine Triphosphate/metabolism
مستخلص: This study evaluated the effect of vitamin D 3 (VIT D 3 ) supplementation on the enzymatic activities and density of ectonucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-5-nucleotidase (E-5'-NT), adenosine deaminase (ADA), as well as the density of P2 × 7R, P2Y12R, A1R, A2AR receptors, IL-1β, and oxidative parameters in type 2 diabetic rats. Forty male Wistar rats were fed a high carbohydrate-high fat diet (HCHFD) and received an intraperitoneal injection containing a single dose of streptozotocin (STZ, 35 mg/kg). Animals were divided into four groups: 1) control; 2) control/VIT D 3 12 µg/kg; 3) diabetic; and 4) diabetic/VIT D 3 12 µg/kg. Results show that VIT D 3 reduced blood glucose, ATP hydrolysis, ADA activity, P2Y12R density (platelets), as well as ATP, ADP, and AMP hydrolysis and ADA activity (synaptosomes). Moreover, VIT D 3 increased insulin levels and AMP hydrolysis (platelets) and improved antioxidant defense. Therefore, we suggest that VIT D 3 treatment modulates hyperglycemia-induced changes via purinergic enzymes and receptor expression, consequently attenuating insulin homeostasis dysregulation in the diabetic state.
Competing Interests: Declaration of competing interest The authors declare that there are no financial interests/personal relationships which may be considered as potential competing interests.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Hyperglycemia; Insulin; Oxidative stress; Purinergic signaling; Vitamin D(3)
المشرفين على المادة: 1C6V77QF41 (Cholecalciferol)
0 (Vitamins)
415SHH325A (Adenosine Monophosphate)
8L70Q75FXE (Adenosine Triphosphate)
0 (Insulins)
تواريخ الأحداث: Date Created: 20240219 Date Completed: 20240408 Latest Revision: 20240408
رمز التحديث: 20240408
DOI: 10.1016/j.jnutbio.2024.109602
PMID: 38373509
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4847
DOI:10.1016/j.jnutbio.2024.109602