دورية أكاديمية
أعرض في EDS

Regulation of stress granule formation in human oligodendrocytes.

التفاصيل البيبلوغرافية
العنوان: Regulation of stress granule formation in human oligodendrocytes.
المؤلفون: Pernin F; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Cui QL; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Mohammadnia A; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Fernandes MGF; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Hall JA; Department of Neurosurgery, McGill University Health Centre, Montreal, QC, Canada., Srour M; Division of Pediatric Neurology, Montreal Children's Hospital, Montreal, QC, Canada., Dudley RWR; Department of Pediatric Neurosurgery, Montreal Children's Hospital, Montreal, QC, Canada., Zandee SEJ; Centre de Recherche Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Klement W; Centre de Recherche Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Prat A; Centre de Recherche Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Salapa HE; Cameco Multiple Sclerosis Neuroscience Research Center, University of Saskatchewan, Saskatoon, SK, Canada., Levin MC; Cameco Multiple Sclerosis Neuroscience Research Center, University of Saskatchewan, Saskatoon, SK, Canada., Moore GRW; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Kennedy TE; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Vande Velde C; Centre de Recherche Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Antel JP; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. jack.antel@mcgill.ca.
المصدر: Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1524. Date of Electronic Publication: 2024 Feb 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Cytoplasmic Granules*/metabolism , Multiple Sclerosis*/metabolism, Humans ; Stress Granules ; Oligodendroglia ; Cytokines/metabolism ; Stress, Physiological
مستخلص: Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular response to stress. Here we show SGs in OLs in active and inactive areas of MS lesions as well as in normal-appearing white matter. In cultures of primary human adult brain derived OLs, metabolic stress conditions induce transient SG formation in these cells. Combining pro-inflammatory cytokines, which alone do not induce SG formation, with metabolic stress results in persistence of SGs. Unlike sodium arsenite, metabolic stress induced SG formation is not blocked by the integrated stress response inhibitor. Glycolytic inhibition also induces persistent SGs indicating the dependence of SG formation and disassembly on the energetic glycolytic properties of human OLs. We conclude that SG persistence in OLs in MS reflects their response to a combination of metabolic stress and pro-inflammatory conditions.
(© 2024. The Author(s).)
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المشرفين على المادة: 0 (Cytokines)
تواريخ الأحداث: Date Created: 20240219 Date Completed: 20240221 Latest Revision: 20240222
رمز التحديث: 20240223
مُعرف محوري في PubMed: PMC10876533
DOI: 10.1038/s41467-024-45746-6
PMID: 38374028
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-45746-6