دورية أكاديمية
Addressing diagnostic dilemmas in eosinophilic esophagitis using esophageal epithelial eosinophil-derived neurotoxin.
| العنوان: | Addressing diagnostic dilemmas in eosinophilic esophagitis using esophageal epithelial eosinophil-derived neurotoxin. |
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| المؤلفون: | Thomas J; Center for Digestive Health and Nutrition, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA., Hopson P; Department of Pediatric Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA., Deb C; Pediatric Specialty Diagnostic Gastroenterology Translational Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA., Bornstein J; Center for Digestive Health and Nutrition, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA., Mehta D; Center for Digestive Health and Nutrition, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA., Bittar K; Center for Digestive Health and Nutrition, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA., Smadi Y; Center for Digestive Health and Nutrition, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida, USA. |
| المصدر: | Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2024 Feb; Vol. 78 (2), pp. 304-312. Date of Electronic Publication: 2023 Dec 27. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [Hoboken, New Jersey] : Wiley Original Publication: [New York, N.Y.] : Raven Press, [c1982- |
| مواضيع طبية MeSH: | Enteritis* , Eosinophil-Derived Neurotoxin*/chemistry , Eosinophil-Derived Neurotoxin*/metabolism , Eosinophilia*/diagnosis , Eosinophilia*/pathology , Eosinophilic Esophagitis*/diagnosis , Eosinophilic Esophagitis*/pathology , Gastritis*, Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Young Adult ; Eosinophils/pathology ; Retrospective Studies |
| مستخلص: | Objectives: Eosinophil-derived neurotoxin (EDN) is a viable marker of eosinophilic esophagitis (EoE) disease activity. We studied the utility of measuring EDN from esophageal epithelial brushings for diagnosing EoE, focusing on two scenarios: (1) cases of exclusive distal eosinophilia and (2) cases of discrepancy between endoscopy and histology. Methods: Records of patients who underwent esophagogastroduodenoscopy (EGD) with EDN measured via esophageal brushings at Arnold Palmer Hospital for Children in Orlando, Florida from January 2014 to October 2018 were retrospectively reviewed. Demographics, clinical, endoscopic, and histologic data were collected. Results: We reviewed 231 patient records (66.7% male, mean age 10.3 years, range 1-22 years). EDN values correlated with endoscopic reference score (EREFS) and peak eosinophil count (PEC) (Spearman's rho = 0.756 (p < 0.001) and 0.824 (p < 0.001) respectively). Average PEC, EREFS, and EDN concentrations were higher in patients with active EoE than in controls or patients with EoE in remission (inactive). When grouping patients based on esophageal eosinophilia distribution, EDN mirrored PEC, and EREFS. Patients with exclusive distal eosinophilia had lower EDN concentrations than those with eosinophilia in >1 level of the esophagus (23.8 ± 46.1 mcg/mL vs. 171.3 ± 205.8 mcg/mL respectively, p < 0.001). EDN values were more consistent with EREFS in cases of discrepancies between endoscopic findings and pathology (p < 0.001). Conclusion: EDN measured in esophageal brushing samples reflects disease activity objectively and accurately. It also offers significant value in cases of exclusive distal esophageal eosinophilia and when discrepancies exist between endoscopy and histology. (© 2023 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) |
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| معلومات مُعتمدة: | Gastrointestinal Translational Laboratory of Arnold Palmer Hospital for Children, Orlando, Florida |
| فهرسة مساهمة: | Keywords: children; dysphagia; endoscopy; histology |
| المشرفين على المادة: | EC 3.1.- (Eosinophil-Derived Neurotoxin) |
| SCR Disease Name: | Eosinophilic enteropathy |
| تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240221 Latest Revision: 20240304 |
| رمز التحديث: | 20240305 |
| DOI: | 10.1002/jpn3.12054 |
| PMID: | 38374551 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-4801 |
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| DOI: | 10.1002/jpn3.12054 |