دورية أكاديمية
Evaluation of therapeutic and toxic levels of serum digoxin concentration: a cross-sectional study from a tertiary hospital.
| العنوان: | Evaluation of therapeutic and toxic levels of serum digoxin concentration: a cross-sectional study from a tertiary hospital. |
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| المؤلفون: | Koca HB; Department of Medical Biochemistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey. bugra.koca@afsu.edu.tr., Oncu S, Becit-Kizilkaya M, Gokaslan S |
| المصدر: | European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2024 Feb; Vol. 28 (3), pp. 1036-1043. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rome : Verduci, [1997- |
| مواضيع طبية MeSH: | Heart Failure* , Atrial Fibrillation*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Digoxin/adverse effects ; Cross-Sectional Studies ; Cardiotonic Agents/therapeutic use ; Tertiary Care Centers ; Creatinine ; Potassium |
| مستخلص: | Objective: Digoxin is a cardiac glycoside for treating heart failure and atrial fibrillation. Despite its limited therapeutic range and complex pharmacokinetic properties, this medication continues to be frequently prescribed. This study aimed to evaluate the serum digoxin concentration (SDC) at therapeutic, subtherapeutic, and toxic levels and explore the factors affecting these levels in patients receiving digoxin therapy for heart failure. Patients and Methods: In this descriptive and cross-sectional study, the data were obtained from the electronic system of patients who presented to Afyonkarahisar Health Sciences University. For the SDC, the reference range was accepted as 0.5-0.9 ng/mL, and the upper limit was 2.0 ng/mL. The patient's demographic characteristics, comorbidities, and laboratory findings were evaluated. The Mann-Whitney U test, Chi-square test, and logistic regression analysis were used. p<0.05 was considered statistically significant. Results: The data of 419 patients (mean age: 65.9±16.1 years, 68.5% women) were evaluated. The mean SDC was 1.11±1.01 ng/mL, and it was below 0.5 ng/mL in 24.3% of the patients, 0.5-0.9 ng/mL in 23.4%, 0.9-2 ng/mL in 41.3%, and over 2 ng/mL in 11.1%. Age, male gender, the presence of diabetes mellitus, and high HbA1c values were found to be associated with greater SDC levels, but this was not statistically significant. The presence of renal failure, elevated creatinine and magnesium levels, and potassium, sodium, and calcium levels outside the normal limits significantly increased the SDC. High creatinine and low/high potassium values significantly affected the detection of SDC at the toxic level. Conclusions: The measurement of SDC levels holds significance not only in the monitoring of toxicity but also in ensuring adherence to the recommended therapeutic range during therapy. It is recommended to exercise caution in terms of risk factors such as age, kidney function test results, and blood electrolyte levels. |
| المشرفين على المادة: | 73K4184T59 (Digoxin) 0 (Cardiotonic Agents) AYI8EX34EU (Creatinine) RWP5GA015D (Potassium) |
| تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240221 Latest Revision: 20240221 |
| رمز التحديث: | 20240221 |
| DOI: | 10.26355/eurrev_202402_35339 |
| PMID: | 38375708 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2284-0729 |
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| DOI: | 10.26355/eurrev_202402_35339 |