دورية أكاديمية
Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension.
| العنوان: | Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension. |
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| المؤلفون: | Brito LC; Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil.; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA., Azevêdo LM; Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil., Amaro-Vicente G; Laboratory of Autonomic Control of Circulation, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil., Costa LR; Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil., da Silva Junior ND; Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil., Halliwill JR; Department of Human Physiology, University of Oregon, Eugene, OR, USA., Rondon MUPB; Laboratory of Autonomic Control of Circulation, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil., Forjaz CLM; Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo, Brazil. |
| المصدر: | The Journal of physiology [J Physiol] 2024 Mar; Vol. 602 (6), pp. 1049-1063. Date of Electronic Publication: 2024 Feb 20. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Blackwell : Cambridge Univ. Press Original Publication: London, Cambridge Univ. Press. |
| مواضيع طبية MeSH: | Hypertension*/therapy , Cardiovascular System*, Humans ; Aged ; Baroreflex/physiology ; Blood Pressure/physiology ; Heart ; Sympathetic Nervous System/physiology ; Heart Rate/physiology ; Muscle, Skeletal |
| مستخلص: | The blood pressure-lowering effect of aerobic training is preceded by improving cardiovascular autonomic control. We previously demonstrated that aerobic training conducted in the evening (ET) induces a greater decrease in blood pressure than morning training (MT). To study whether the greater blood pressure decrease after ET occurs through better cardiovascular autonomic regulation, this study aimed to compare MT versus ET on muscle sympathetic nerve activity (MSNA) and baroreflex sensitivity (BRS) in treated patients with hypertension. Elderly patients treated for hypertension were randomly allocated into MT (n = 12, 07.00-10.00 h) or ET (n = 11, 17.00-20.00 h) groups. Both groups trained for 10 weeks, 3 times/week, cycling for 45 min at moderate intensity. Beat-to-beat blood pressure (finger photoplethysmography), heart rate (electrocardiography) and MSNA (microneurography) were assessed at the initial and final phases of the study at baseline and during sequential bolus infusions of sodium nitroprusside and phenylephrine (modified-Oxford technique) to evaluate cardiac and sympathetic BRS. Mean blood pressure decreased significantly after ET but not after MT (-9 ± 11 vs. -1 ± 8 mmHg, P = 0.042). MSNA decreased significantly only after ET with no change after MT (-12 ± 5 vs. -3 ± 7 bursts/100 heart beats, P = 0.013). Sympathetic BRS improved after ET but not after MT (-0.8 ± 0.7 vs. 0.0 ± 0.8 bursts/100 heart beats/mmHg, P = 0.052). Cardiac BRS improved similarly in both groups (ET: +1.7 ± 1.8 vs. MT: +1.4 ± 1.9 ms/mmHg, P (© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.) |
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| معلومات مُعتمدة: | FAPESP 2018/05226-0 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); FAPESP 2022/12605-3 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); OHSU Fellowship for Diversity in Research (OFDIR); CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); 304436/2018-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); 313152/2020-9 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); 302309/2022-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); CAPES-PROEX #88887.480725/2020-00 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
| فهرسة مساهمة: | Keywords: aerobic exercise; autonomic nervous system; circadian rhythms; hypertension |
| تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240318 Latest Revision: 20240318 |
| رمز التحديث: | 20240318 |
| DOI: | 10.1113/JP285966 |
| PMID: | 38377223 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-7793 |
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| DOI: | 10.1113/JP285966 |