دورية أكاديمية
Nonlinear elasticity and short-range mechanical coupling govern the rate and symmetry of mouth opening in Hydra .
العنوان: | Nonlinear elasticity and short-range mechanical coupling govern the rate and symmetry of mouth opening in Hydra . |
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المؤلفون: | Goel T; Department of Physics, University of California San Diego, La Jolla, CA 92093, USA.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Department of Biology, University of Maryland, College Park, MD 20742, USA., Adams EM; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA., Bialas AL; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA., Tran CM; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Rowe T; Department of Physics, University of California San Diego, La Jolla, CA 92093, USA., Martin S; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA., Chandler M; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA., Schubert J; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA., Diamond PH; Department of Physics, University of California San Diego, La Jolla, CA 92093, USA., Collins ES; Department of Physics, University of California San Diego, La Jolla, CA 92093, USA.; Department of Biology, Swarthmore College, Swarthmore, PA 19081, USA.; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
المصدر: | Proceedings. Biological sciences [Proc Biol Sci] 2024 Feb 28; Vol. 291 (2017), pp. 20232123. Date of Electronic Publication: 2024 Feb 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Royal Society of London Country of Publication: England NLM ID: 101245157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2954 (Electronic) Linking ISSN: 09628452 NLM ISO Abbreviation: Proc Biol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Royal Society of London, c1990- |
مواضيع طبية MeSH: | Hydra*/physiology, Animals ; Mouth/physiology ; Epithelium ; Biomechanical Phenomena ; Neurons |
مستخلص: | Hydra has a tubular bilayered epithelial body column with a dome-shaped head on one end and a foot on the other. Hydra lacks a permanent mouth: its head epithelium is sealed. Upon neuronal activation, a mouth opens at the apex of the head which can exceed the body column diameter in seconds, allowing Hydra to ingest prey larger than itself. While the kinematics of mouth opening are well characterized, the underlying mechanism is unknown. We show that Hydra mouth opening is generated by independent local contractions that require tissue-level coordination. We model the head epithelium as an active viscoelastic nonlinear spring network. The model reproduces the size, timescale and symmetry of mouth opening. It shows that radial contractions, travelling inwards from the outer boundary of the head, pull the mouth open. Nonlinear elasticity makes mouth opening larger and faster, contrary to expectations. The model correctly predicts changes in mouth shape in response to external forces. By generating innervated : nerve-free chimera in experiments and simulations, we show that nearest-neighbour mechanical signalling suffices to coordinate mouth opening. Hydra mouth opening shows that in the absence of long-range chemical or neuronal signals, short-range mechanical coupling is sufficient to produce long-range order in tissue deformations. |
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فهرسة مساهمة: | Keywords: chimera; epithelium; nearest-neighbour interaction; strain hardening; viscoelastic |
تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240222 Latest Revision: 20240224 |
رمز التحديث: | 20240224 |
مُعرف محوري في PubMed: | PMC10878823 |
DOI: | 10.1098/rspb.2023.2123 |
PMID: | 38378148 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1471-2954 |
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DOI: | 10.1098/rspb.2023.2123 |