دورية أكاديمية
Measurement of plasma total calcium before plasma free ionized calcium - a possibility with affordable pitfalls.
| العنوان: | Measurement of plasma total calcium before plasma free ionized calcium - a possibility with affordable pitfalls. |
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| المؤلفون: | Kjøller TS; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Lind BS; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Schwarz P; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark., Jørgensen HL; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
| المصدر: | Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2024 Feb; Vol. 84 (1), pp. 38-43. Date of Electronic Publication: 2024 Feb 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0404375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7686 (Electronic) Linking ISSN: 00365513 NLM ISO Abbreviation: Scand J Clin Lab Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo, Medisinsk Fysiologisk Forenings Forlag. |
| مواضيع طبية MeSH: | Hypercalcemia*/diagnosis , Hypocalcemia*/diagnosis, Humans ; Calcium ; Electrolytes ; Albumins |
| مستخلص: | Free ionized calcium (fCa) is considered the gold standard for assessing calcium status in patients, but it is relatively expensive and is associated with several preanalytical and analytical error sources. We investigated the feasibility of using a reflex test that involves first measuring total calcium (tCa) and if out of reference range, then measure fCa, with expectation of reducing the number of fCa measurements. We used data from 1815 unique patients with concurrent measurement of fCa, tCa and albumin adjusted calcium (aCa). Patients were stratified by albumin level, and the association of fCa to tCa and aCa respectively was assessed with linear regression. The regression analysis showed the best linearity for tCa and aCa at albumin <35 g/L ( R 2 : 0.80-0.90), and the poorest at albumin >40 g/L ( R 2 : tCa 0.58; aCa 0.59). We examined the accuracy of hypo- and hypercalcemia classifications for tCa, aCa and the reflex test. aCa had more misclassifications of hypo- and hypercalcemia than tCa, with respectively 25% and 21%. Implementation of the reflex test would correct any false hypo- or hypercalcemia classified by tCa, leaving only false negative results corresponding to 9% of all tCa measurements. False negative results were on average 0.04 mmol/L above or below the reference range of fCa. Implementation of the reflex test reduces the number of fCa by 68% without major errors diagnosing hyper- or hypocalcemia. |
| فهرسة مساهمة: | Keywords: Endocrinology; bone metabolism; laboratory management; laboratory routines and automation; laboratory screening; medical biochemistry |
| المشرفين على المادة: | SY7Q814VUP (Calcium) 0 (Electrolytes) 0 (Albumins) |
| تواريخ الأحداث: | Date Created: 20240221 Date Completed: 20240313 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| DOI: | 10.1080/00365513.2024.2317756 |
| PMID: | 38381053 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7686 |
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| DOI: | 10.1080/00365513.2024.2317756 |