دورية أكاديمية
Vitamin B 12 deficiency in diabetic patients treated with metformin: A narrative review.
| العنوان: | Vitamin B |
|---|---|
| المؤلفون: | Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 211-63, Jordan., Al Kreasha R; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 211-63, Jordan., Aqel S; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 211-63, Jordan., Saeed A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 211-63, Jordan., Al-Qudimat AR; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, 3050, Doha, Qatar., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, 3050, Doha, Qatar. ralzoubi@hamad.qa.; Department of Biomedical Sciences, College of Health Sciences, QU-Health, Qatar University, Doha, 2713, Qatar. ralzoubi@hamad.qa.; Department of Chemistry, Jordan University of Science and Technology, P.O.Box 3030, Irbid, 22110, Jordan. ralzoubi@hamad.qa. |
| المصدر: | Irish journal of medical science [Ir J Med Sci] 2024 Feb 21. Date of Electronic Publication: 2024 Feb 21. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Academy of Medicine of Ireland Country of Publication: Ireland NLM ID: 7806864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-4362 (Electronic) Linking ISSN: 00211265 NLM ISO Abbreviation: Ir J Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Dublin : Royal Academy of Medicine of Ireland |
| مستخلص: | Metformin is the most prescribed oral hypoglycemic drug and is considered by many health practitioners as the first-line treatment for non-insulin-dependent diabetes mellitus (T2DM). It is used either as a monotherapy or adjuvant to other anti-hyperglycemic agents. Most of its side effects are usually mild and self-limiting. However, several studies have shown an association between the use of metformin and low vitamin B (© 2024. The Author(s).) |
| References: | Kerner W, Brückel J (2014) Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes 122(07):384–386. (PMID: 25014088) A. D. Association (2020) 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes—2020. Diabetes Care 43(Supplement 1):S14–S31. Susan van D et al (2010) The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil 17(1_suppl):s3–s8. W. H. Organization (2019) Classification of diabetes mellitus. W. H. Organization (2016) Global report on diabetes. World Health Organization, Geneva, p 2016. Suvi K et al (2017) IDF diabetes atlas, 8th edn 2017. Brussels, Belgium, International Diabetes Federation. Ahmed MA (2016) Metformin and vitamin B12 deficiency: where do we stand? J Pharm Pharm Sci 19(3):382–398. (PMID: 27806244) Rabbia Rana MF, Iftikhar T, Makki MU (2017) Metformin use and vitamin B12 deficiency in patients with type-2 diabetes mellitus. JMH S 11(3):1–3. Niafar M et al (2015) The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med 10(1):93–102. (PMID: 25502588) Alwan A (2011) Global status report on noncommunicable diseases 2010. World Health Organization. Lin Y, Sun Z (2010) Current views on type 2 diabetes. J Endocrinol 204(1):1. (PMID: 19770178) Baerlocher MO, Asch M, Myers A (2013) Metformin and intravenous contrast. CMAJ 185(1):E78–E78. (PMID: 230480793537815) Abu Jama’ah WJ et al (2016) Studying the association of metformin dose with peripheral neuropathy in diabetic patients at Jordanian Royal Medical Services. Eur Sci J 12(6). Ahmed MA, Muntingh G, Rheeder P (2016) Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol 17(1):44. (PMID: 277164235054613) Koppad AK et al (2017) Evaluation of serum vitamin B12 levels in type 2 diabetes patients on metformin therapy attending a tertiary care hospital. J Evid Based Med Healthc 4(90):5399–5404. Raizada N et al (2017) Serum vitamin B12 levels in type 2 diabetes patients on metformin compared to those never on metformin: a cross-sectional study. Indian J Endocrinol Metab 21(3):424–428. (PMID: 285535995434727) Verma VK et al (2017) Vitamin B12 deficiency among vegetarian and non-vegetarian diabetic population receiving prolonged metformin based oral hypoglycemic agents therapy. Int J Adv Med 4(4). Alharbi TJ et al (2018) The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus. PLoS ONE 13(10):e0204420. (PMID: 303211836188756) Alvarez M et al (2019) Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study. Endocr Connect 8(10):1324–1329. (PMID: 315189916790897) Al Saeed RR, Baraja MA (2021) Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia. Saudi Med J 42(2):161–165. (PMID: 335637347989282) Khan TU, Arshad R, Adhami SUZ (2021) Prevalence of vitamin B12 deficiency in type II diabetic patients using metformin. Prof Med J 28(09):1322–1325. Malla D et al (2021) Prevalence of vitamin B12 deficiency in patients with type II diabetes mellitus on metformin. J Diabetes Endocrinol Assoc Nepal 5(1):39–43. Bell DS (2010) Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J 103(3):265–267. (PMID: 20134380) Satyanarayana A et al (2011) Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS ONE 6(11):e26747. (PMID: 220694683206053) Ahmed SS et al (2023) Is vitamin B12 deficiency a risk factor for gastroparesis in patients with type 2 diabetes? Diabetol Metab Syndr 15(1):33. (PMID: 368551729976380) Singla R et al (2019) Vitamin B12 deficiency is endemic in Indian population: a perspective from North India. Indian J Endocrinol Metab 23(2):211–214. (PMID: 311611056540890) Kibirige D, Mwebaze R (2013) Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? J Diabetes Metab Disord 12(1):17. (PMID: 236517303649932) Alshammari AN, Iqbal R, Baksh IP (2019) Vitamin B12 deficiency and the knowledge and practice of physicians regarding screening for vitamin B12 deficiency among type 2 diabetic patients on metformin in selected hospitals in Riyadh, Saudi Arabia. J Family Med Prim Care 8(7):2306–2311. (PMID: 314632476691434) Alhaji JH (2022) Vitamin B12 deficiency in patients with diabetes on metformin: Arab countries. Nutrients 14(10). Nand L et al (2020) Vitamin B12 deficiency in patients of type 2 diabetes mellitus treated with metformin: a cross section observational study from a tertiary care centre in Sub-Himalayan region of North India. Int J Res Med Sci 8(4). Krishnan GD, Zakaria MH, Yahaya N (2020) Prevalence of vitamin B12 deficiency and its associated factors among patients with type 2 diabetes mellitus on metformin from a district in Malaysia. J ASEAN Fed Endocr Soc 35(2):163–168. (PMID: 334421877784158) Gao L et al (2023) The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: a multicenter cross-sectional study. J Diabetes 15(9):765–776. (PMID: 3731002810509512) Lala K, Lala D, Duggad S (2020) Serum vitamin B12 and homocysteine levels in type 2 diabetes patients on metformin. Int J Adv Med 7(9). Sekhri T et al (2019) Vitamin B12 deficiency in patients with type 2 diabetes. Int J Adv Med 6(3). Soutelo J et al (2020) Relationship between dose of metformin and vitamin B12 deficiency. CurR Res Diabetes Obes J 12(5):117–124. Ali K et al (2020) Association of vitamin B12 deficiency and metformin use in patients presenting with type ii diabetes mellitus. Pak Armed Forces Med J 70(5):1495–1498. Sakyi S et al (2020) Profiling immuno-metabolic mediators of vitamin B12 deficiency among metformin-treated type II diabetes patients in Ghana. Miyan Z, Waris N (2020) Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan. BMJ Open Diabetes Res Care 8(1):e001151. (PMID: 324487867252966) Lata Kanyal M, Mujawar A (2019) Status of vitamin b12 in type 2 diabetes mellitus patients taking metformin based oral hypoglycemic agent-a cross sectional study. IJBAMR 1(9):18–26. Kim J et al (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Medicine (Baltimore) 98(46):e17918. (PMID: 31725641) Zalaket J, Wehbe T, Abou Jaoude E (2018) Vitamin B12 deficiency in diabetic subjects taking metformin: a cross sectional study in a Lebanese cohort. J Nutr Intermed Metab 11:9–13. Khan A, Shafiq I, Hassan Shah M (2017) Prevalence of vitamin B12 deficiency in patients with type II diabetes mellitus on metformin: a study from Khyber Pakhtunkhwa. Cureus 9(8):e1577. (PMID: 290571895647126) Beulens JW et al (2015) Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol 52(1):47–53. (PMID: 24908579) Ko S-H et al (2014) Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J Korean Med Sci 29(7):965–972. (PMID: 250452294101785) Sato Y et al (2013) Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Endocr J E13-0332. de Groot-Kamphuis D et al (2013) Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin. Neth J Med 71(7):386. (PMID: 24038568) Romero JMC, Lozano JMR (2012) Vitamin B12 in type 2 diabetic patients treated with metformin. Endocrinología y Nutrición (English Edition) 59(8):487–490. Reinstatler L et al (2012) Association of biochemical B Liu K et al (2011) Metformin-associated vitamin B12 deficiency in the elderly. Asian J Gerontol Geriatr 6(2):82–87. Kancherla V et al (2017) Long-term metformin therapy and monitoring for vitamin B12 deficiency among older veterans. J Am Geriatr Soc 65(5):1061–1066. (PMID: 281822655435502) Wile DJ, Toth C (2010) Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care 33(1):156–161. (PMID: 19846797) de Jager J et al (2010) Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 340:c2181. (PMID: 204889102874129) Rodríguez-Gutiérrez R et al (2017) Metformin use and vitamin B12 deficiency: untangling the association. Am J Med Sci 354(2):165–171. (PMID: 28864375) Raizada N et al (2017) Serum vitamin B12 levels in type 2 diabetes patients on metformin compared to those never on metformin: a cross-sectional study. Indian J Endocrinol Metab 21(3):424. (PMID: 285535995434727) Adetunji O et al (2009) Metformin and anaemia: myth or reality? Pract Diabetes Int 26(7):265–266. Elhadd T et al (2018) Metformin use is not associated with B12 deficiency or neuropathy in patients with type 2 diabetes mellitus in Qatar. Front Endocrinol 9:248. Flory J, Lipska K (2019) Metformin in 2019. JAMA 321(19):1926–1927. (PMID: 310090437552083) Corcoran C, Jacobs TF (2021) Metformin. StatPearls [Internet]. Rena G, Hardie DG, Pearson ER (2017) The mechanisms of action of metformin. Diabetologia 60(9):1577–1585. (PMID: 287760865552828) Bailey C, Wilcock C, Scarpello J (2008) Metformin and the intestine. Diabetologia 51(8):1552–1553. (PMID: 18528677) LaMoia TE, Shulman GI (2021) Cellular and molecular mechanisms of metformin action. Endocr Rev 42(1):77–96. (PMID: 32897388) Viollet B et al (2012) Cellular and molecular mechanisms of metformin: an overview. Clin Sci 122(6):253–270. Sinclair A, Dunning T, Colagiuri S (2013) Managing older people with type 2 diabetes: global guideline. International Diabetes Federation. Nathan D et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetologia 49(8):1711–1721. (PMID: 16802130) Rizzo G, Laganà AS (2020) A review of vitamin B12. Mol Nutr 105–129. Watanabe F (2007) Vitamin B12 sources and bioavailability. Exp Biol Med 232(10):1266–1274. Allen LH (2008) Causes of vitamin B12 and folate deficiency. Food Nutr Bull 29(2_suppl1):S20–S34. (PMID: 18709879) Watanabe F et al (2002) Characterization and bioavailability of vitamin B12-compounds from edible algae. J Nutr Sci Vitaminol 48(5):325–331. (PMID: 12656203) Shane B (2008) Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull 29(2_suppl1):S5–S16. (PMID: 18709878) Shipton MJ, Thachil J (2015) Vitamin B12 deficiency - a 21st century perspective. Clin Med (Lond) 15(2):145–150. (PMID: 25824066) Lindenbaum J et al (1988) Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318(26):1720–1728. (PMID: 3374544) Devalia V et al (2014) Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol 166(4):496–513. (PMID: 24942828) Quadros EV (2010) Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol 148(2):195–204. (PMID: 19832808) Allen LH (2009) How common is vitamin B-12 deficiency? Am J Clin Nutr 89(2):693S–696S. (PMID: 19116323) Green R et al (2017) Vitamin B 12 deficiency. Nat Rev Dis Primers 3(1):1–20. da Silva L, McCray S (2009) Vitamin B12: no one should be without it. Pract Gastroenterol 33(34):39–42. Al-Batayneh KM et al (2018) Association between MTHFR 677C> T polymorphism and vitamin B12 deficiency: a case-control study. J Med Biochem 37(2):141. (PMID: 305813506294092) Al-Batayneh KM et al (2019) Homologous G776G variant of transcobalamin-II gene is linked to vitamin B12 deficiency. Int J Vitam Nutr Res. Lam JR et al (2013) Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA 310(22):2435–2442. (PMID: 24327038) Tomkin G et al (1971) Vitamin-B12 status of patients on long-term metformin therapy. Br Med J 2(5763):685–687. (PMID: 55560531796258) Sparre Hermann L, Nilsson B, Wettre S (2004) Vitamin B12 status of patients treated with metformin: a cross-sectional cohort study. Br J Diabetes Vasc Dis 4(6):401–406. Singh A et al (2013) Association of B12 deficiency and clinical neuropathy with metformin use in type 2 diabetes patients. J Postgrad Med 59(4):253. (PMID: 24346380) Kang D et al (2014) Higher prevalence of metformin-induced vitamin B 12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study. PLoS ONE 9(10):e109878. (PMID: 252990544192538) Yang W et al (2019) Associations between metformin use and vitamin B(12) levels, anemia, and neuropathy in patients with diabetes: a meta-analysis. J Diabetes 11(9):729–743. (PMID: 30615306) Chapman LE, Darling AL, Brown JE (2016) Association between metformin and vitamin B(12) deficiency in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab 42(5):316–327. (PMID: 27130885) Caspary W, Creutzfeldt W (1971) Analysis of the inhibitory effect of biguanides on glucose absorption: inhibition of active sugar transport. Diabetologia 7(5):379–385. (PMID: 5134258) Buvat D (2004) Use of metformin is a cause of vitamin B12 deficiency. Am Fam Physician 69(2):264. (PMID: 14765765) Bauman WA et al (2000) Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 23(9):1227–1231. (PMID: 10977010) Ting RZ et al (2006) Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med 166(18):1975–1979. (PMID: 17030830) Campbell JM et al (2018) Metformin use associated with reduced risk of dementia in patients with diabetes: a systematic review and meta-analysis. J Alzheimers Dis 65(4):1225–1236. (PMID: 301494466218120) Moore EM et al (2013) Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care 36(10):2981–2987. (PMID: 240093013781568) Wakeman M, Archer DT (2020) Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels? Diabetes Metab Syndr Obes 13:2093–2108. (PMID: 326068687308123) Miller JW (2018) Proton pump inhibitors, H2-receptor antagonists, metformin, and vitamin B-12 deficiency: clinical implications. Adv Nutr 9(4):511s–518s. (PMID: 300322236054240) Long AN et al (2012) Vitamin B12 deficiency associated with concomitant metformin and proton pump inhibitor use. Diabetes Care 35(12):e84–e84. (PMID: 231731453507616) Sahin M et al (2007) Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 21(2):118–123. (PMID: 17331860) Aroda VR et al (2016) Long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study. J Clin Endocrinol Metab 101(4):1754–1761. (PMID: 269006414880159) |
| فهرسة مساهمة: | Keywords: B12 deficiency; Diabetes mellitus; Metformin; T2DM |
| تواريخ الأحداث: | Date Created: 20240221 Latest Revision: 20240221 |
| رمز التحديث: | 20240221 |
| DOI: | 10.1007/s11845-024-03634-4 |
| PMID: | 38381379 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1863-4362 |
|---|---|
| DOI: | 10.1007/s11845-024-03634-4 |