دورية أكاديمية
Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling.
| العنوان: | Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling. |
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| المؤلفون: | Vlasova AD; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Bukhalovich SM; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Bagaeva DF; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Polyakova AP; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Ilyinsky NS; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Nesterov SV; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Tsybrov FM; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Bogorodskiy AO; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Zinovev EV; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Mikhailov AE; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Vlasov AV; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia., Kuklin AI; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia., Borshchevskiy VI; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia., Bamberg E; Max Planck Institute of Biophysics, Frankfurt am Main, Germany., Uversky VN; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. vuversky@usf.du., Gordeliy VI; Institut de Biologie Structurale Jean-Pierre Ebel, Université Grenoble Alpes-Commissariat à l'Energie Atomique et aux Energies Alternatives-CNRS, 38027 Grenoble, France. valentin.gordeliy@ibs.fr. |
| المصدر: | Chemical Society reviews [Chem Soc Rev] 2024 Apr 02; Vol. 53 (7), pp. 3327-3349. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Chemical Society Country of Publication: England NLM ID: 0335405 Publication Model: Electronic Cited Medium: Internet ISSN: 1460-4744 (Electronic) Linking ISSN: 03060012 NLM ISO Abbreviation: Chem Soc Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Letchworth : Chemical Society Original Publication: London, Chemical Society. |
| مواضيع طبية MeSH: | Rhodopsins, Microbial*/genetics , Optogenetics*, Signal Transduction |
| مستخلص: | Microbial rhodopsin (MRs) ion channels and pumps have become invaluable optogenetic tools for neuroscience as well as biomedical applications. Recently, MR-optogenetics expanded towards subcellular organelles opening principally new opportunities in optogenetic control of intracellular metabolism and signaling via precise manipulations of organelle ion gradients using light. This new optogenetic field expands the opportunities for basic and medical studies of cancer, cardiovascular, and metabolic disorders, providing more detailed and accurate control of cell physiology. This review summarizes recent advances in studies of the cellular metabolic processes and signaling mediated by optogenetic tools targeting mitochondria, endoplasmic reticulum (ER), lysosomes, and synaptic vesicles. Finally, we discuss perspectives of such an optogenetic approach in both fundamental and applied research. |
| المشرفين على المادة: | 0 (Rhodopsins, Microbial) |
| تواريخ الأحداث: | Date Created: 20240223 Date Completed: 20240403 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| DOI: | 10.1039/d3cs00699a |
| PMID: | 38391026 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1460-4744 |
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| DOI: | 10.1039/d3cs00699a |