دورية أكاديمية
أعرض في EDS

Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease.

التفاصيل البيبلوغرافية
العنوان: Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease.
المؤلفون: Silva-Batista C; Exercise Neuroscience Research Group, University of São Paulo, São Paulo 05508-070, Brazil.; Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA., Lira J; Exercise Neuroscience Research Group, University of São Paulo, São Paulo 05508-070, Brazil.; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.; School of Physical Education and Sport, University of São Paulo, São Paulo 05508-030, Brazil., Coelho DB; Biomedical Engineering, Federal University of ABC, São Bernardo do Campo 09210-170, Brazil., de Lima-Pardini AC; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada., Nucci MP; Department of Radiology, University of São Paulo, São Paulo 05508-090, Brazil., Mattos ECT; Instituto de Ciencias e Tecnologia, Universidade Federal de São Paulo, São Paulo 09913-030, Brazil., Magalhaes FH; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil., Barbosa ER; Movement Disorders Clinic, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05508-070, Brazil., Teixeira LA; School of Physical Education and Sport, University of São Paulo, São Paulo 05508-030, Brazil., Amaro Junior E; Department of Radiology, University of São Paulo, São Paulo 05508-090, Brazil., Ugrinowitsch C; School of Physical Education and Sport, University of São Paulo, São Paulo 05508-030, Brazil., Horak FB; Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
المصدر: Brain sciences [Brain Sci] 2024 Feb 15; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Individuals with Parkinson's disease (PD) and freezing of gait (FOG) have a loss of presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MLR) has connections to the reticulospinal tract that mediates inhibitory interneurons responsible for modulating PSI and APAs. Here, we hypothesized that MLR activity during step initiation would explain the loss of PSI during APAs for step initiation in FOG (freezers). Freezers (n = 34) were assessed in the ON-medication state. We assessed the beta of blood oxygenation level-dependent signal change of areas known to initiate and pace gait (e.g., MLR) during a functional magnetic resonance imaging protocol of an APA task. In addition, we assessed the PSI of the soleus muscle during APA for step initiation, and clinical (e.g., disease duration) and behavioral (e.g., FOG severity and APA amplitude for step initiation) variables. A linear multiple regression model showed that MLR activity (R 2 = 0.32, p = 0.0006) and APA amplitude (R 2 = 0.13, p = 0.0097) explained together 45% of the loss of PSI during step initiation in freezers. Decreased MLR activity during a simulated APA task is related to a higher loss of PSI during APA for step initiation. Deficits in central and spinal inhibitions during APA may be related to FOG pathophysiology.
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فهرسة مساهمة: Keywords: H-reflex; anticipatory postural adjustment; freezers; mesencephalic locomotor region; presynaptic inhibition; step initiation
تواريخ الأحداث: Date Created: 20240223 Latest Revision: 20240225
رمز التحديث: 20240225
مُعرف محوري في PubMed: PMC10887111
DOI: 10.3390/brainsci14020178
PMID: 38391752
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3425
DOI:10.3390/brainsci14020178