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PoxiPred: An Artificial-Intelligence-Based Method for the Prediction of Potential Antigens and Epitopes to Accelerate Vaccine Development Efforts against Poxviruses.

التفاصيل البيبلوغرافية
العنوان: PoxiPred: An Artificial-Intelligence-Based Method for the Prediction of Potential Antigens and Epitopes to Accelerate Vaccine Development Efforts against Poxviruses.
المؤلفون: Martinez GS; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4H7, Canada.; Department of Pediatrics, Izaak Walton Killam (IWK) Health Center, Canadian Center for Vaccinology (CCfV), Halifax, NS B3H 4H7, Canada.; Laboratory of Immunity, Shantou University Medical College, Shantou 512025, China.; BioForge Canada Limited, Halifax, B3N3B9, NS, Canada., Dutt M; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4H7, Canada.; Department of Pediatrics, Izaak Walton Killam (IWK) Health Center, Canadian Center for Vaccinology (CCfV), Halifax, NS B3H 4H7, Canada.; Laboratory of Immunity, Shantou University Medical College, Shantou 512025, China.; BioForge Canada Limited, Halifax, B3N3B9, NS, Canada., Kelvin DJ; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4H7, Canada.; Department of Pediatrics, Izaak Walton Killam (IWK) Health Center, Canadian Center for Vaccinology (CCfV), Halifax, NS B3H 4H7, Canada.; Laboratory of Immunity, Shantou University Medical College, Shantou 512025, China.; BioForge Canada Limited, Halifax, B3N3B9, NS, Canada., Kumar A; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4H7, Canada.; Department of Pediatrics, Izaak Walton Killam (IWK) Health Center, Canadian Center for Vaccinology (CCfV), Halifax, NS B3H 4H7, Canada.; Laboratory of Immunity, Shantou University Medical College, Shantou 512025, China.; BioForge Canada Limited, Halifax, B3N3B9, NS, Canada.
المصدر: Biology [Biology (Basel)] 2024 Feb 17; Vol. 13 (2). Date of Electronic Publication: 2024 Feb 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2012-
مستخلص: Poxviridae is a family of large, complex, enveloped, and double-stranded DNA viruses. The members of this family are ubiquitous and well known to cause contagious diseases in humans and other types of animals as well. Taxonomically, the poxviridae family is classified into two subfamilies, namely Chordopoxvirinae (affecting vertebrates) and Entomopoxvirinae (affecting insects). The members of the Chordopoxvirinae subfamily are further divided into 18 genera based on the genome architecture and evolutionary relationship. Of these 18 genera, four genera, namely Molluscipoxvirus, Orthopoxvirus, Parapoxvirus, and Yatapoxvirus, are known for infecting humans. Some of the popular members of poxviridae are variola virus, vaccine virus, Mpox (formerly known as monkeypox), cowpox, etc. There is still a pressing demand for the development of effective vaccines against poxviruses. Integrated immunoinformatics and artificial-intelligence (AI)-based methods have emerged as important approaches to design multi-epitope vaccines against contagious emerging infectious diseases. Despite significant progress in immunoinformatics and AI-based techniques, limited methods are available to predict the epitopes. In this study, we have proposed a unique method to predict the potential antigens and T-cell epitopes for multiple poxviruses. With PoxiPred, we developed an AI-based tool that was trained and tested with the antigens and epitopes of poxviruses. Our tool was able to locate 3191 antigen proteins from 25 distinct poxviruses. From these antigenic proteins, PoxiPred redundantly located up to five epitopes per protein, resulting in 16,817 potential T-cell epitopes which were mostly (i.e., 92%) predicted as being reactive to CD8+ T-cells. PoxiPred is able to, on a single run, identify antigens and T-cell epitopes for poxviruses with one single input, i.e., the proteome file of any poxvirus.
References: Lab Anim Sci. 1971 Dec;21(6):1023-31. (PMID: 4331925)
Infect Genet Evol. 2010 Jan;10(1):50-9. (PMID: 19833230)
J Immunol Res. 2017;2017:2680160. (PMID: 29445754)
Viruses. 2020 Jan 24;12(2):. (PMID: 31991671)
Methods Mol Biol. 2014;1184:333-64. (PMID: 25048134)
Cureus. 2022 Jul 3;14(7):e26531. (PMID: 35928395)
J Med Chem. 1987 Jul;30(7):1126-35. (PMID: 3599020)
J Vet Med Sci. 2022 Aug 1;84(8):1093-1100. (PMID: 35691931)
J Virol. 2015 Sep;89(18):9348-67. (PMID: 26136578)
J Gen Virol. 2023 May;104(5):. (PMID: 37195882)
Sci Rep. 2017 Jun 16;7(1):3734. (PMID: 28623312)
Immunotargets Ther. 2020 Feb 26;9:13-30. (PMID: 32161726)
BMC Bioinformatics. 2021 May 5;22(1):231. (PMID: 33952199)
J Virol. 2003 Jul;77(13):7590-600. (PMID: 12805459)
Annu Rev Immunol. 2020 Apr 26;38:123-145. (PMID: 32045313)
Front Microbiol. 2022 Nov 28;13:1065894. (PMID: 36519172)
BMC Bioinformatics. 2007 Jan 05;8:4. (PMID: 17207271)
Cell Host Microbe. 2022 Dec 14;30(12):1662-1670.e4. (PMID: 36463861)
J Med Microbiol. 1972 Nov;5(4):Pxiv. (PMID: 4345769)
Microbiol Rev. 1991 Mar;55(1):80-122. (PMID: 1851533)
J Vet Sci. 2023 May;24(3):e42. (PMID: 37271510)
Sci Rep. 2021 Feb 5;11(1):3238. (PMID: 33547334)
J Cell Biochem. 2023 May;124(5):701-715. (PMID: 36946432)
J Infect Dis. 1969 Jan;119(1):80-8. (PMID: 4303797)
Drug Discov Today. 2020 Jun;25(6):1034-1042. (PMID: 32205198)
Nat Med. 2022 Aug;28(8):1569-1572. (PMID: 35750157)
Ther Adv Vaccines Immunother. 2022 May 21;10:25151355221100218. (PMID: 35647486)
Comput Biol Chem. 2022 Jun;98:107688. (PMID: 35561658)
Front Immunol. 2021 Sep 15;12:712488. (PMID: 34603286)
معلومات مُعتمدة: CIHR OV2-170357 Canada CAPMC CIHR; CIHR MZ1 187236 Canada CAPMC CIHR
فهرسة مساهمة: Keywords: Poxviridae; antigens; artificial intelligence; epitopes; vaccine
تواريخ الأحداث: Date Created: 20240223 Latest Revision: 20240225
رمز التحديث: 20240225
مُعرف محوري في PubMed: PMC10887159
DOI: 10.3390/biology13020125
PMID: 38392343
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-7737
DOI:10.3390/biology13020125