Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma.

التفاصيل البيبلوغرافية
العنوان:	Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma.
المؤلفون:	Phuyathip W; Department of Community Health, Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, 47000, Thailand., Putthisen S; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Panawan O; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Ma-In P; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Teeravirote K; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Sintusen P; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Udomkitkosol S; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Detarya M; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Luang S; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Mahalapbutr P; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Sato T; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, 305-8565, Japan., Kuno A; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, 305-8565, Japan., Chuangchaiya S; Department of Community Health, Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, 47000, Thailand. sriwipa.c@ku.th., Silsirivanit A; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. atitsil@kku.ac.th.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand. atitsil@kku.ac.th.
المصدر:	Histochemistry and cell biology [Histochem Cell Biol] 2024 May; Vol. 161 (5), pp. 423-434. Date of Electronic Publication: 2024 Feb 23.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin : Springer,
مواضيع طبية MeSH:	Cholangiocarcinoma/metabolism , Cholangiocarcinoma/pathology , Bile Duct Neoplasms/metabolism , Bile Duct Neoplasms/pathology , Plant Lectins/metabolism , Polysaccharides/metabolism , Polysaccharides/chemistry , Receptors, N-Acetylglucosamine/metabolism, Animals ; Humans ; Cricetinae ; Male ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Neoplasm Metastasis ; Female ; Middle Aged ; Cell Movement/drug effects
مستخلص:	Aberrant glycosylation is an important factor in facilitating tumor progression and therapeutic resistance. In this study, using Wisteria floribunda agglutinin (WFA), we examined the expression of WFA-binding glycans (WFAG) in cholangiocarcinoma (CCA). The results showed that WFAG was highly detected in precancerous and cancerous lesions of human CCA tissues, although it was rarely detected in normal bile ducts. The positive signal of WFAG in the cancerous lesion accounted for 96.2% (50/52) of the cases. Overexpression of WFAG was significantly associated with lymph node and distant metastasis (P < 0.05). The study using the CCA hamster model showed that WFAG is elevated in preneoplastic and neoplastic bile ducts as early as 1 month after being infected with liver fluke and exposed to N-nitrosodimethylamine. Functional analysis was performed to reveal the role of WFAG in CCA. The CCA cell lines KKU-213A and KKU-213B were treated with WFA, followed by migration assay. Our data suggested that WFAG facilitates the migration of CCA cells via the activation of the Akt and ERK signaling pathways. In conclusion, we have demonstrated the association of WFAG with carcinogenesis and metastasis of CCA, suggesting its potential as a target for the treatment of the disease. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	Graduate School Fellowship Program Graduate School, Kasetsart University; Fundamental Fund 65 Khon Kaen University
فهرسة مساهمة:	Keywords: Cholangiocarcinoma; Glycosylation; Lectin
المشرفين على المادة:	0 (Plant Lectins) 0 (Polysaccharides) 0 (Receptors, N-Acetylglucosamine) 0 (wisteria lectin)
تواريخ الأحداث:	Date Created: 20240223 Date Completed: 20240425 Latest Revision: 20240425
رمز التحديث:	20240426
DOI:	10.1007/s00418-024-02270-4
PMID:	38393396
قاعدة البيانات:	MEDLINE

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تدمد:	1432-119X
DOI:	10.1007/s00418-024-02270-4