دورية أكاديمية

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.

التفاصيل البيبلوغرافية
العنوان: Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.
المؤلفون: Kimura TC; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil., de Lima-Souza RA; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil., Maciel TF; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil., Kowalski LP; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil., Coutinho-Camillo CM; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Egal ESA; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.; Biorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, Utah, USA., Altemani A; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil., Mariano FV; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil. fevimariano@gmail.com.
المصدر: Head and neck pathology [Head Neck Pathol] 2024 Feb 23; Vol. 18 (1), pp. 12. Date of Electronic Publication: 2024 Feb 23.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Country of Publication: United States NLM ID: 101304010 Publication Model: Electronic Cited Medium: Internet ISSN: 1936-0568 (Electronic) Linking ISSN: 1936055X NLM ISO Abbreviation: Head Neck Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: June 2011- : New York : Springer Science+ Business Media
Original Publication: Secaucus, NJ : Humana Press
مواضيع طبية MeSH: MicroRNAs*/genetics , Salivary Gland Neoplasms*/pathology , Carcinoma*, Humans ; Biomarkers ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Prognosis ; Salivary Glands/metabolism ; Biomarkers, Tumor/genetics
مستخلص: Background: Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.
Methods: This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications.
Results: In this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs.
Conclusion: In the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Diagnostic; MicroRNAs; Prognosis; Salivary gland neoplasms; Therapy
المشرفين على المادة: 0 (MicroRNAs)
0 (Biomarkers)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240223 Date Completed: 20240226 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10891027
DOI: 10.1007/s12105-023-01603-4
PMID: 38393615
قاعدة البيانات: MEDLINE
الوصف
تدمد:1936-0568
DOI:10.1007/s12105-023-01603-4