دورية أكاديمية
Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors.
| العنوان: | Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors. |
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| المؤلفون: | Stern ME; University of Cologne, Department of Ophthalmology, Cologne, Germany; IOBA, Department of Ophthalmology, University of Valladolid, Valladolid, Spain. Electronic address: michaelestern4@gmail.com., Theofilopoulos AN; Scripps Research Institute, Department of Immunology & Microbiology, La Jolla, CA, USA., Steven P; University of Cologne, Department of Ophthalmology, Cologne, Germany; University of Cologne, Department of Internal Medicine - 1, Cologne, Germany., Niederkorn JY; Southwestern School of Medicine, Department of Ophthalmology, Dallas, TX, USA., Fox R; Scripps Hospital, Department of Rheumatology, La Jolla, CA, USA., Calonge M; IOBA, Department of Ophthalmology, University of Valladolid, Valladolid, Spain., Scheid C; University of Cologne, Department of Internal Medicine - 1, Cologne, Germany., Pflugfelder SC; Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA. |
| المصدر: | The ocular surface [Ocul Surf] 2024 Apr; Vol. 32, pp. 130-138. Date of Electronic Publication: 2024 Feb 22. |
| نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101156063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-5913 (Electronic) Linking ISSN: 15420124 NLM ISO Abbreviation: Ocul Surf Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : [Philadelphia, PA] : Elsevier Inc. Original Publication: New York, N.Y. : Ethis Communications, [c2003]- |
| مواضيع طبية MeSH: | Keratoconjunctivitis Sicca*/immunology , Immunity, Innate* , Autoimmune Diseases*/immunology, Humans ; Conjunctiva/immunology ; Conjunctiva/pathology ; Tears/immunology ; Tears/metabolism |
| مستخلص: | The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which are typically self limited, but when persistent and unresolved may provoke pathogenic innate and adaptive immune reactions. Our understanding of the pathophysiological mechanisms by which systemic autoimmune diseases cause dry eye inducing ocular surface inflammation continues to evolve. Conjunctival immune tone responds to self or foreign danger signals (including desiccating stress) on the ocular surface with an initial non-specific innate inflammatory response. If unchecked, this can lead to activation of dendritic cells that present antigen and prime T and B cells resulting in an adaptive immune reaction. These reactions generally resolve, but dysfunctional, hyper-responsive immune cells found in systemic autoimmune diseases that are recruited to the ocular surface can amplify inflammatory stress responses in the ocular surface and glandular tissues and result in autoimmune reactions that disrupt tear stability and lead to chronic dry eye disease. We here propose that unique features of the ocular surface immune system and the impact of systemic immune dysregulation in autoimmune diseases, can predispose to development of dry eye disease, and exacerbate severity of existing dry eye. Competing Interests: Declaration of competing interest M. Stern – Consultantships - Kala. A. Theofilopoulos - None. P. Steven- Bausch & Lomb, URSA-PHARM, Marinomed, Bitop J. Niederkorn - None. R. Fox - None. M. Calonge - None. C. Scheid - None. S. Pflugfelder - None. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autoimmunity; Dry eye; Immune tone; Innate immunity; Keratoconjunctivitis sicca |
| تواريخ الأحداث: | Date Created: 20240223 Date Completed: 20240427 Latest Revision: 20240513 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1016/j.jtos.2024.02.003 |
| PMID: | 38395195 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1937-5913 |
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| DOI: | 10.1016/j.jtos.2024.02.003 |