دورية أكاديمية
Stroke and high-risk TIA outcomes with reduction of treatment duration when treatment initiated in emergency rooms (SHORTER-study).
| العنوان: | Stroke and high-risk TIA outcomes with reduction of treatment duration when treatment initiated in emergency rooms (SHORTER-study). |
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| المؤلفون: | Alhazzani A; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Alajlan FS; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Alkhathaami AM; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Al-Senani FM; National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Muayqil TA; Neurology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alghamdi SA; King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia., AlKawi A; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., AlZahrani S; King Fahad General Hospital, Ministry of Health, Jeddah, Saudi Arabia., Bakheet M; King Abdullah Medical City, Mecca, Saudi Arabia., Aljohani M; King Salman ibn Abdulaziz Medical City, Madinah, Saudi Arabia., Taher N; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Almutairi A; Prince Sultan Military Medical City, Riyadh, Saudi Arabia., AlQarni M; King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alsalman S; King Fahad Hospital Hofuf, Al-Ahsa, Riyadh, Saudi Arabia., Alqahtani SA; College of Medicine, King Khalid University, Abha, Saudi Arabia., Almansour N; King Saud Medical City, Riyadh, Saudi Arabia., Abukhamsin L; Dammam Medical Complex, Dammam, Saudi Arabia., Mouminah A; King Abdullah Medical Complex, Jeddah, Saudi Arabia., Almodarra N; National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Mohamed G; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Almodhy M; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Albogumi E; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Alzawahmah M; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Alreshaid A; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Akhtar N; Hamad Medical Corporation, Doha, Qatar., Hussain MS; Cleveland Clinic, Cleveland, OH, USA., Albers GW; Stanford University, Stanford, CA, USA., Shuaib A; University of Alberta, Edmonton, AB, Canada. |
| المصدر: | International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2024 Aug; Vol. 19 (7), pp. 830-834. Date of Electronic Publication: 2024 Mar 16. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Thousand Oaks, CA : SAGE Publications Original Publication: Oxford, UK : Blackwell Pub., c2005- |
| مواضيع طبية MeSH: | Ischemic Attack, Transient*/drug therapy , Platelet Aggregation Inhibitors*/therapeutic use , Clopidogrel*/therapeutic use , Clopidogrel*/administration & dosage , Emergency Service, Hospital* , Stroke*/prevention & control , Stroke*/epidemiology, Humans ; Aspirin/therapeutic use ; Aspirin/administration & dosage ; Ischemic Stroke/prevention & control ; Male ; Female ; Treatment Outcome ; Aged ; Middle Aged ; Dual Anti-Platelet Therapy/methods ; Time Factors ; Saudi Arabia/epidemiology ; Secondary Prevention/methods |
| مستخلص: | Background: Following transient ischemic attack (TIA) and minor stroke, the risk of recurrent stroke can be significantly reduced with short-duration dual antiplatelet therapy (DAPT). We wish to investigate whether 10 days of DAPT is as effective as 21 days' treatment. Study Design: This is an open-label, randomized, parallel-group study comparing whether 10 days of DAPT treatment (ASA + clopidogrel) is non-inferior to 21 days of DAPT in patients with acute ischemic stroke (AIS) or high-risk TIA. In both groups, DAPT is started within 24 hours of symptom onset. This study is being conducted in approximately 15 study sites in the Kingdom of Saudi Arabia. The planned sample size is 1932. Outcomes: Non-inferiority of 10 days compared to 21 days of DAPT in the prevention of the composite endpoint of stroke and death at 90 days in AIS/TIA patients. The primary safety outcome is major intra-cranial and systemic hemorrhage. Study Period: Enrolment started in the second quarter of 2023, and the completion of the study is expected in the fourth quarter of 2025. Discussion: The trial is expected to show that 10 days of DAPT is non-inferior for the prevention of early recurrence of vascular events in patients with high-risk TIAs and minor strokes. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: Antiplatelet therapy; Aspirin; TIA; antithrombotic; minor stroke; stroke prevention |
| المشرفين على المادة: | 0 (Platelet Aggregation Inhibitors) A74586SNO7 (Clopidogrel) R16CO5Y76E (Aspirin) |
| تواريخ الأحداث: | Date Created: 20240223 Date Completed: 20240803 Latest Revision: 20240803 |
| رمز التحديث: | 20240804 |
| DOI: | 10.1177/17474930241237120 |
| PMID: | 38395748 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1747-4949 |
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| DOI: | 10.1177/17474930241237120 |