دورية أكاديمية
Evaluation of the effect of therapeutic durations on small ruminant bacterial pneumonia.
| العنوان: | Evaluation of the effect of therapeutic durations on small ruminant bacterial pneumonia. |
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| المؤلفون: | Girma S; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.; Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany., Bekele T; School of Veterinary Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia., Leta S; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia., Tegegne DT; National Agricultural Biotechnology Research Center, Ethiopian Institute of Agricultural Research Center, P.O. Box 249, Holeta, Ethiopia., Demissie T; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia., Hadush B; Department of Veterinary Clinical Medicine and Epidemiology, College of Veterinary Sciences, Mekelle University, Mekelle, Tigray, Ethiopia., Aragaw K; Faculty of Veterinary Medicine, Hawassa University, P.O. Box 05, Hawassa, Ethiopia., Tufa TB; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia., Tolera TS; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia., Tafess K; Institute of Pharmaceutical Sciences, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia. ttafess@gmail.com.; Department of Applied Biology, School of Applied Natural Science, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia. ttafess@gmail.com. |
| المصدر: | BMC veterinary research [BMC Vet Res] 2024 Feb 24; Vol. 20 (1), pp. 68. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Randomized Controlled Trial, Veterinary; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, 2005- |
| مواضيع طبية MeSH: | Goat Diseases*/drug therapy , Goat Diseases*/microbiology , Oxytetracycline*/therapeutic use , Pasteurella multocida* , Pneumonia, Bacterial*/drug therapy , Pneumonia, Bacterial*/veterinary , Sheep Diseases*/drug therapy , Sheep Diseases*/microbiology, Animals ; Ethiopia ; Goats ; Hospitals, Animal ; Hospitals, Teaching ; Sheep |
| مستخلص: | Background: Sheep and goat production in Ethiopia is hindered by numerous substandard production systems and various diseases. Respiratory disease complexes (RDC) pose a significant threat to the productivity of these animals. Pneumonia is a common manifestation of respiratory disease complexes and often necessitates a prolonged course of antibiotic treatment. This study aimed to optimize and propose the ideal duration of therapy for pneumonia in sheep and goats. Methods: The study was conducted from February to June 2021 at the Veterinary Teaching Hospital of the College of Veterinary Medicine and Agriculture, Addis Ababa University. The study recruited 54 sheep and goats presented to the hospital for treatment with a confirmed RDC as determined based on clinical signs and bacteriological methods. The animals were randomly allocated to 5 groups each group receiving 10% oxytetracycline (Phenxyl, Phenix, Belgum) intramuscularly for a duration of 3, 4, 5, 6 and 7 consecutive days. The treatment outcomes were assessed by recording vital signs (body temperature, respiratory rate, heart rate, coughing, and nasal discharges), performing lung ultrasonography (L-USG) as well as collection of nasal swabs for bacterial isolation and molecular identification before and after completion of the treatment. An ordered logistic regression model with random effects was employed to determine the optimal therapeutic duration, taking into account the cumulative scores of the outcome variables across the different groups. Results: Among the 54 sheep and goats treated with 10% oxytetracycline, a total of 74.07% (95% CI, 60.35-85.04) achieved complete recovery, as confirmed through clinical, ultrasound, and bacteriological methods. In Group 1 (G1), out of 12 sheep and goats, 8 (83.0%) recovered completely; in Group 2 (G2), out of 11 animals, 9 (82.0%) recovered completely; in Group 3 (G3), out of 11 animals, 10 (93.0%) recovered completely; in Group 4 (G4), out of 9 animals, 9 (100.0%) recovered completely; and in Group 5 (G5), out of 11 animals, 10 (91.0%) recovered completely. Bacteriological examination of nasal swabs indicated involvement of M. hemolytica in 27 (50.00%) and P. multocida in 13 (24.07%) of pneumonic animals. Detection of specific marker genes confirmed only five of the presumptive M. hemolytica isolates, whilst no isolates tested positive for P. multocida. Post-treatment samples collected from recovered animals did not yield any M. hemolytica nor P. multocida. Based on results from clinical signs, L-USG, and bacterial infection variables, the group of sheep and goats treated for seven consecutive days (G5) showed the highest recovery score compared to the other groups, and there was a statistically significant difference (coefficient (β) = - 2.296, p = 0.021) in variable score between G5 and G1. These findings suggest that the administration of 10% oxytetracycline for a full course of seven consecutive days resulted in symptomatic and clinical recovery rates from respiratory disease in sheep and goats. (© 2024. The Author(s).) |
| References: | Vet Med (Auckl). 2022 Apr 24;13:75-83. (PMID: 35497709) J Feline Med Surg. 2016 Feb;18(2):183-4. (PMID: 26810411) BMC Microbiol. 2018 Dec 5;18(1):205. (PMID: 30518323) J Glob Antimicrob Resist. 2020 Mar;20:170-177. (PMID: 31401170) Vet World. 2018 May;11(5):636-641. (PMID: 29915502) Sci Rep. 2023 Jun 2;13(1):9008. (PMID: 37268660) BMC Med Res Methodol. 2011 May 23;11:77. (PMID: 21605357) Small Rumin Res. 2000 Jul 1;37(1-2):1-12. (PMID: 10818297) Vet Med Int. 2014;2014:537501. (PMID: 24977091) Vet World. 2015 Sep;8(9):1073-7. (PMID: 27047201) Vet Med Int. 2014;2014:508304. (PMID: 25028620) Pediatrics. 2007 Apr;119(4):e837-42. (PMID: 17403827) Vet Med Sci. 2023 Jul;9(4):1803-1811. (PMID: 37197762) Pediatr Res. 2019 Nov;86(5):651-654. (PMID: 31288247) BMC Vet Res. 2017 Aug 22;13(1):263. (PMID: 28830505) Trop Anim Health Prod. 2001 Oct;33(5):355-65. (PMID: 11556615) Indian J Exp Biol. 2006 Apr;44(4):321-4. (PMID: 16629376) BMC Vet Res. 2013 Dec 01;9:239. (PMID: 24289236) Cold Spring Harb Perspect Med. 2016 Apr 01;6(4):a025387. (PMID: 26989065) JAMA Intern Med. 2016 Sep 1;176(9):1254-5. (PMID: 27455385) Infect Dis Clin North Am. 2000 Jun;14(2):281-91, vii. (PMID: 10829256) |
| فهرسة مساهمة: | Keywords: Ethiopia; Goat; Oxytetracycline; Respiratory diseases; Sheep; Therapeutic duration |
| المشرفين على المادة: | X20I9EN955 (Oxytetracycline) |
| تواريخ الأحداث: | Date Created: 20240223 Date Completed: 20240226 Latest Revision: 20240412 |
| رمز التحديث: | 20240412 |
| مُعرف محوري في PubMed: | PMC10893678 |
| DOI: | 10.1186/s12917-024-03917-z |
| PMID: | 38395815 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1746-6148 |
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| DOI: | 10.1186/s12917-024-03917-z |