دورية أكاديمية
أعرض في EDS

Pilot Study on the Efficacy and Safety of Long-Term Oral Imepitoin Treatment for Control of (Thunder)Storm-Associated Noise Phobia/Noise Aversion in Dogs Using an Individualized-Dose Titration Approach.

التفاصيل البيبلوغرافية
العنوان: Pilot Study on the Efficacy and Safety of Long-Term Oral Imepitoin Treatment for Control of (Thunder)Storm-Associated Noise Phobia/Noise Aversion in Dogs Using an Individualized-Dose Titration Approach.
المؤلفون: Muñoz Amezcua AC; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA., Jones JM; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA., Griffith EH; Department of Statistics, North Carolina State University, Raleigh, NC 27606, USA., Gruen ME; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
المصدر: Animals : an open access journal from MDPI [Animals (Basel)] 2024 Feb 06; Vol. 14 (4). Date of Electronic Publication: 2024 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
مستخلص: Imepitoin is a low-affinity partial agonist for benzodiazepine binding sites of gamma-aminobutyric acid receptors with anxiolytic effects. It has been shown to reduce anxiety during noise-related events in dogs when given at 30 mg/kg PO BID, although this dose was associated with ataxia and increased appetite in some cases. The objective of this study was to assess its safety and efficacy for storm anxiety when started at 10 mg/kg PO BID and titrated to effect up to 30 mg/kg PO BID during storm season. Significant decreases in anxiety scores were seen in weekly surveys and storm logs (SLs) at 10, 20 and 30 mg/kg PO BID. Serious adverse events (AEs) were not reported in any subject. Ataxia was the most commonly reported non-serious AE (14/33), followed by increased hunger (13/33). The frequency of AEs was higher in the 20 mg/kg PO BID group than in the 10 mg/kg group PO BID. No clinically significant changes were seen in lab work pre- and post-study. In conclusion, Imepitoin given during storm season at doses ranging from 10 to 30 mg/kg PO BID reduced clinical signs of fear and anxiety during storms for the dogs in this study. These findings support the use of an individually titrated dose.
References: CNS Drugs. 2014 Jan;28(1):29-43. (PMID: 24357084)
Can J Psychiatry. 2011 Dec;56(12):707-15. (PMID: 22152639)
Nat Commun. 2022 Oct 12;13(1):6026. (PMID: 36224187)
J Behav Ther Exp Psychiatry. 1981 Sep;12(3):185-8. (PMID: 6119325)
J Vet Pharmacol Ther. 2015 Apr;38(2):160-8. (PMID: 25079881)
Vet Clin North Am Small Anim Pract. 2008 Sep;38(5):1081-106, vii. (PMID: 18672155)
Vet J. 2008 Jul;177(1):80-8. (PMID: 17572119)
Vet Rec. 2021 May;188(9):e18. (PMID: 33960445)
BMC Vet Res. 2015 Aug 28;11:176. (PMID: 26316233)
J Am Vet Med Assoc. 2008 Nov 1;233(9):1420-4. (PMID: 18980494)
Q Rev Biol. 1995 Jun;70(2):165-91. (PMID: 7610234)
Vet Clin North Am Small Anim Pract. 2018 May;48(3):367-386. (PMID: 29397241)
Front Pharmacol. 2018 Nov 01;9:1225. (PMID: 30455643)
J Appl Anim Welf Sci. 1998;1(3):207-26. (PMID: 16363966)
J Am Vet Med Assoc. 2001 Aug 15;219(4):467-73. (PMID: 11518172)
Vet Rec. 2021 Oct;189(7):e453. (PMID: 33993491)
J Am Vet Med Assoc. 1996 Aug 15;209(4):738-42. (PMID: 8756871)
Vet J. 2008 Jan;175(1):18-26. (PMID: 17321766)
J Vet Pharmacol Ther. 2014 Oct;37(5):421-34. (PMID: 24611573)
Vet Rec. 2017 Aug 5;181(6):144. (PMID: 28600446)
Animals (Basel). 2021 Feb 13;11(2):. (PMID: 33668532)
J Vet Intern Med. 2019 Nov;33(6):2675-2684. (PMID: 31568622)
Psychol Rev. 1998 Apr;105(2):325-50. (PMID: 9577241)
Stat Med. 2011 Dec 30;30(30):3560-72. (PMID: 21953305)
BMC Vet Res. 2015 Sep 02;11:228. (PMID: 26330063)
BMC Vet Res. 2017 Jun 13;13(1):173. (PMID: 28610629)
معلومات مُعتمدة: 543798 Boehringer Ingelheim Vetmedica GmbH
فهرسة مساهمة: Keywords: antiepileptic; anxiety; anxiolytic; clinical trial; imepitoin; noise; phobia; storm
تواريخ الأحداث: Date Created: 20240224 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10886229
DOI: 10.3390/ani14040545
PMID: 38396513
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2615
DOI:10.3390/ani14040545