دورية أكاديمية
أعرض في EDS

uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.

التفاصيل البيبلوغرافية
العنوان: uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.
المؤلفون: He Y; Department of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Døssing KBV; Department of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Rossing M; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark., Bagger FO; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Kjaer A; Department of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 07; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Glioblastoma*/metabolism , Receptors, Urokinase Plasminogen Activator*/genetics , Receptors, Urokinase Plasminogen Activator*/metabolism, Humans ; Sequence Analysis, RNA ; Signal Transduction ; Tumor Microenvironment/genetics ; Single-Cell Gene Expression Analysis ; Biomarkers, Tumor
مستخلص: Urokinase plasminogen activator receptor (uPAR) encoded by the PLAUR gene is known as a clinical marker for cell invasiveness in glioblastoma multiforme (GBM). It is additionally implicated in various processes, including angiogenesis and inflammation within the tumor microenvironment. However, there has not been a comprehensive study that depicts the overall functions and molecular cooperators of PLAUR with respect to intra-tumoral subtypes of GBM. Using single-cell RNA sequencing data from 37 GBM patients, we identified PLAUR as a marker gene for two distinct subtypes in GBM. One subtype is featured by inflammatory activities and the other subtype is marked by ECM remodeling processes. Using the whole-transcriptome data from single cells, we are able to uncover the molecular cooperators of PLAUR for both subtypes without presuming biological pathways. Two protein networks comprise the molecular context of PLAUR , with each of the two subtypes characterized by a different dominant network. We concluded that targeting PLAUR directly influences the mechanisms represented by these two protein networks, regardless of the subtype of the targeted cell.
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معلومات مُعتمدة: no. 670261 ERC Advanced Grant; 668532 Click- It; grant 126 Danish National Research Foundation
فهرسة مساهمة: Keywords: CD44; ECM degradation; FN1; GBM cell invasiveness; PLAUR; inflammatory microenvironment; single-cell RNA sequencing; uPAR
المشرفين على المادة: 0 (Receptors, Urokinase Plasminogen Activator)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240308
رمز التحديث: 20240309
مُعرف محوري في PubMed: PMC10889167
DOI: 10.3390/ijms25041998
PMID: 38396677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25041998