دورية أكاديمية
أعرض في EDS

Serological Antibodies against Kidney, Liver, and Spleen Membrane Antigens as Potential Biomarkers in Patients with Immune Disorders.

التفاصيل البيبلوغرافية
العنوان: Serological Antibodies against Kidney, Liver, and Spleen Membrane Antigens as Potential Biomarkers in Patients with Immune Disorders.
المؤلفون: Hernandez-Suarez L; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain.; Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain., Diez-Martin E; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain.; Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain., Egiguren-Ortiz J; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain.; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain., Fernandez R; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain., Etxebarria A; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain., Astigarraga E; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain., Miguelez C; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.; Neurodegenerative Diseases Group, BioBizkaia Health Research Institute, 48940 Barakaldo, Spain., Ramirez-Garcia A; Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain., Barreda-Gómez G; Department of Research and Development, IMG Pharma Biotech S.L., 48170 Zamudio, Spain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 07; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Spleen* , Lupus Nephritis*, Humans ; Rats ; Animals ; Antigens ; Liver ; Autoantibodies ; Kidney ; Graft Rejection
مستخلص: Immune disorders arise from complex genetic and environmental factors, which lead to dysregulation at the cellular and inflammatory levels and cause tissue damage. Recent research highlights the crucial role of reactive antibodies in autoimmune diseases and graft rejection, but their complex determination poses challenges for clinical use. Therefore, our study aimed to ascertain whether the presence of reactive antibodies against membrane antigens in tissues from both animal models and humans could serve as biomarkers in patients with autoimmune disorders. To address this issue, we examined the binding profile of serological antibodies against a diverse panel of cell membranes from the spleen, liver, and kidney tissues of monkeys, rats, and humans. After developing the cell membrane microarrays, human sera were immunologically assayed. The study was first conducted on sera from two groups, healthy subjects and patients with inflammatory and autoimmune disorders, and then optimized for kidney transplant patient sera. A significant increase in antibody reactivity against specific monkey kidney and spleen membranes was observed in the serum of patients with lupus nephritis, while kidney transplant patients showed a significant enhancement against human tissues and human embryonic kidney 293 cells. These results show the potential importance for clinical and basic research purposes of studying the presence of specific IgG against membrane antigens in patients' serum as potential biomarkers of immune disorders. However, it is important to note that these results need to be verified in further studies with a larger sample size to confirm their relevance.
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معلومات مُعتمدة: 004-B2/2022 Basque Government; 005-B2/2021 Basque Government; 006-B2/2021 Basque Government; PIFIND21/02 University of the Basque Country; PIFIND21/04 University of the Basque Country; IT1657-22 Basque Government; exp. PTQ2019-010650 Spanish Ministry of Science and Innovation Center for Technological and Industrial Development (CDTI)
فهرسة مساهمة: Keywords: autoimmune disorders; inflammation; microarray; reactive antibodies
المشرفين على المادة: 0 (Antigens)
0 (Autoantibodies)
تواريخ الأحداث: Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10888476
DOI: 10.3390/ijms25042025
PMID: 38396703
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25042025