تقرير
أعرض في EDS

Improved Graft Function following Desensitization of Anti-AT 1 R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.

التفاصيل البيبلوغرافية
العنوان: Improved Graft Function following Desensitization of Anti-AT 1 R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.
المؤلفون: Jung R; Department of Pharmacy, Lahey Hospital and Medical Center, Burlington, MA 01805, USA., Ly K; Department of Pharmacy, Temple University Hospital, Philadelphia, PA 19140, USA., Taniguchi M; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA.; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA., Arriola AG; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA.; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA., Gravante C; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA., Shinn D; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA., Mathew L; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA., Hamad E; Heart and Vascular Institute, Section of Cardiology, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA., Geier S; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA.; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA., Liacini A; Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA.; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 12; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 12.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Kidney Transplantation* , Heart Transplantation*/adverse effects, Female ; Humans ; Middle Aged ; Autoantibodies ; HLA Antigens ; Graft Rejection
مستخلص: HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT 1 R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.
References: Hum Immunol. 2016 Dec;77(12):1154-1158. (PMID: 27542526)
Transplantation. 2010 Dec 27;90(12):1473-7. (PMID: 21030904)
Transplantation. 2014 Mar 15;97(5):595-601. (PMID: 24162250)
J Heart Lung Transplant. 2001 Nov;20(11):1233-6. (PMID: 11704486)
N Engl J Med. 2005 Feb 10;352(6):558-69. (PMID: 15703421)
Nat Rev Nephrol. 2016 Aug;12(8):484-95. (PMID: 27345243)
Curr Opin Organ Transplant. 2016 Aug;21(4):427-32. (PMID: 27258575)
Am J Transplant. 2003 Feb;3(2):167-77. (PMID: 12603212)
Transplantation. 2022 Feb 1;106(2):373-380. (PMID: 33988339)
J Heart Lung Transplant. 2018 May;37(5):537-547. (PMID: 29452978)
Nephrol Dial Transplant. 2010 Jan;25(1):307-10. (PMID: 19846396)
J Heart Lung Transplant. 2017 May;36(5):540-545. (PMID: 27916323)
J Heart Lung Transplant. 2010 Aug;29(8):914-56. (PMID: 20643330)
Transfus Apher Sci. 2017 Aug;56(4):520-524. (PMID: 28774825)
Am J Transplant. 2011 Feb;11(2):312-9. (PMID: 21219570)
Interact Cardiovasc Thorac Surg. 2016 Mar;22(3):292-7. (PMID: 26675563)
Kidney Int. 2019 Jul;96(1):189-201. (PMID: 31005275)
Transplantation. 2012 Nov 15;94(9):919-24. (PMID: 23034559)
Clin Transplant. 2021 Jul;35(7):e14333. (PMID: 33914369)
Nephrology (Carlton). 2015 Jul;20(7):467-73. (PMID: 25726938)
Am J Transplant. 2013 Oct;13(10):2577-89. (PMID: 23941128)
فهرسة مساهمة: Keywords: AT1R; antibody-mediated rejection; autoantibodies; orthotopic heart transplantation; rejection
المشرفين على المادة: 0 (Autoantibodies)
0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10888554
DOI: 10.3390/ijms25042218
PMID: 38396895
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25042218