دورية أكاديمية
أعرض في EDS

Genomic Variants and Worldwide Epidemiology of Breast Cancer: A Genome-Wide Association Studies Correlation Analysis.

التفاصيل البيبلوغرافية
العنوان: Genomic Variants and Worldwide Epidemiology of Breast Cancer: A Genome-Wide Association Studies Correlation Analysis.
المؤلفون: da Costa Nunes GG; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., de Freitas LM; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., Monte N; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., Gellen LPA; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., Santos AP; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., de Moraes FCA; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., da Costa ACA; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., de Lima MC; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., Fernandes MR; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil., Dos Santos SEB; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil.; Laboratory of Human and Medical Genetics, Institute of Biological Science, Federal University of Pará, Belém 66075-110, Brazil., Dos Santos NPC; Research Center of Oncology, Federal University of Pará Belém, Belém 66073-000, Brazil.
المصدر: Genes [Genes (Basel)] 2024 Jan 23; Vol. 15 (2). Date of Electronic Publication: 2024 Jan 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Genome-Wide Association Study* , Breast Neoplasms*/epidemiology , Breast Neoplasms*/genetics, Humans ; Female ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Genomics
مستخلص: Breast cancer (BCa) is the most common cancer and leading cause of cancer death among women globally. This can be explained by the genetic factor of this disease. This article aims to correlate the epidemiological data, worldwide incidence, and mortality of BCa with the Single-Nucleotide Polymorphisms (SNPs) associated with the susceptibility and severity in different populations. Two hundred and forty genetic variants associated with BCa susceptibility/severity were selected from the literature through Genome-Wide Association Studies (GWAS). The allele frequencies were obtained from the 1000 Genomes Project, and the epidemiological data were obtained from the World Health Organization (WHO). The BCa incidence, mortality rates, and allele frequencies of the variants were evaluated using Pearson's correlation. Our study demonstrated that 11 SNPs (rs3817578, rs4843437, rs3754934, rs61764370, rs780092, rs2290203, rs10411161, rs6001930, rs16886165, rs8051542 and rs4973768) were significantly correlated with the epidemiological data in different ethnic groups. Seven polymorphisms (rs3817578, rs3754934, rs780092, rs2290203, rs10411161, rs6001930 and rs16886165) were inversely correlated with the incidence rate and four polymorphisms (rs4843437, rs61764370, rs8051542 and rs4973768) were directly correlated with the incidence rate. African and South-East Asian populations have a lower risk of developing BCa when evaluated in terms of genetic factors since they possess variants characterized as protective, as their higher incidence is associated with a lower frequency of BCa cases. The genetic variants investigated here are likely to predispose individuals to BCa. The genetic study described here is promising for implementing personalized strategies to screen for breast cancer in diverse populations.
References: Nat Commun. 2022 Dec 22;13(1):7886. (PMID: 36550158)
Sci Rep. 2017 Jun 1;7(1):2660. (PMID: 28572685)
J Int Med Res. 2023 Apr;51(4):3000605231166517. (PMID: 37128157)
J Biol Chem. 2021 Jan-Jun;296:100543. (PMID: 33722605)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
Int Immunopharmacol. 2023 Nov;124(Pt A):110848. (PMID: 37633233)
Br J Radiol. 2022 Feb 1;95(1130):20211033. (PMID: 34905391)
Sci Rep. 2023 Sep 27;13(1):16268. (PMID: 37758759)
Nat Genet. 2009 May;41(5):585-90. (PMID: 19330027)
J Obes. 2023 Oct 4;2023:6661858. (PMID: 37829557)
Mini Rev Med Chem. 2023 Aug 23;:. (PMID: 37612862)
PLoS One. 2010 Oct 20;5(10):e13510. (PMID: 20975957)
Front Endocrinol (Lausanne). 2020 Apr 23;11:245. (PMID: 32390948)
Pigment Cell Melanoma Res. 2019 Mar;32(2):303-314. (PMID: 30457212)
Mol Genet Genomics. 2020 May;295(3):537-561. (PMID: 32048005)
Front Endocrinol (Lausanne). 2021 Feb 24;11:615846. (PMID: 33716953)
Eur J Pharmacol. 2020 Aug 15;881:173201. (PMID: 32442541)
Int J Gen Med. 2023 Sep 11;16:4109-4120. (PMID: 37720173)
JAMA Oncol. 2018 Apr 01;4(4):476-482. (PMID: 29346471)
Genes (Basel). 2019 Feb 18;10(2):. (PMID: 30781715)
CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
Mol Genet Genomic Med. 2019 Sep;7(9):e871. (PMID: 31317673)
Oncotarget. 2016 Jun 14;7(24):36711-36718. (PMID: 27167340)
فهرسة مساهمة: Keywords: breast cancer; epidemiology; genetic risk variants; population; severity; susceptibility
تواريخ الأحداث: Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240616
رمز التحديث: 20240616
مُعرف محوري في PubMed: PMC10888129
DOI: 10.3390/genes15020145
PMID: 38397135
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes15020145