دورية أكاديمية
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Design of Liquid Formulation Based on F127-Loaded Natural Dimeric Flavonoids as a New Perspective Treatment for Leishmaniasis.

التفاصيل البيبلوغرافية
العنوان: Design of Liquid Formulation Based on F127-Loaded Natural Dimeric Flavonoids as a New Perspective Treatment for Leishmaniasis.
المؤلفون: da Costa CS; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Marques EM; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., do Nascimento JR; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.; Postgraduate Program in Chemistry, Institute of Chemistry, UNESP-Estadual University Paulista Júlio de Mesquita Filho, Araraquara 14800-060, Brazil., Lima VAS; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Santos-Oliveira R; Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, Brazil.; Laboratory of Nanoradiopharmacy, Rio de Janeiro State University, Rio de Janeiro 23070-200, Brazil., Figueredo AS; Laboratory of Immunophysiology, Center for Biological and Health Sciences, Federal University of Maranhão, São Luís 65080-805, Brazil., de Jesus CM; Laboratory of Immunophysiology, Center for Biological and Health Sciences, Federal University of Maranhão, São Luís 65080-805, Brazil., de Souza Nunes GC; Research Nucleus in Pharmaceutical Sciences Program, State University of Maringá, Maringá 87020-900, Brazil., Brandão CM; Department of Chemistry, Federal Institute of Maranhão, São Luis 65075-441, Brazil., de Jesus ET; Department of Chemistry, Federal Institute of Maranhão, São Luis 65075-441, Brazil., Sa MC; Department of Chemistry, Federal Institute of Maranhão, São Luis 65075-441, Brazil., Tanaka AA; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Braga G; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Santos ACF; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., de Lima RB; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Silva LA; Laboratory of Immunophysiology, Center for Biological and Health Sciences, Federal University of Maranhão, São Luís 65080-805, Brazil., Alencar LMR; Laboratory of Biophysics and Nanosystems, Department of Physics, Federal University of Maranhão, São Luís 65080-805, Brazil., da Rocha CQ; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil., Gonçalves RS; Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2024 Feb 08; Vol. 16 (2). Date of Electronic Publication: 2024 Feb 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Infectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging to heal, resulting in disfiguring scars. Moreover, it has the potential to extend from the skin to the mucous membranes of the nose, mouth, and throat in both humans and various animals. Given the limited effectiveness and AMR of current drugs, the exploration of new substances has emerged as a promising alternative for ATL treatment. Arrabidaea brachypoda (DC). Bureau is a native Brazilian plant rich in dimeric flavonoids, including Brachydin (BRA), which displays antimicrobial activity, but still little has been explored regarding the development of therapeutic formulations. In this work, we present the design of a low-cost liquid formulation based on the use of Pluronic F127 for encapsulation of high BRA concentration (LF-B500). The characterization techniques revealed that BRA-loaded F127 micelles are well-stabilized in an unusual worm-like form. The in vitro cytotoxicity assay demonstrated that LF-B500 was non-toxic to macrophages but efficient in the inactivation of forms of Leishmania amazonensis promastigotes with IC 50 of 16.06 µg/mL. The results demonstrated that LF-B500 opened a new perspective on the use of liquid formulation-based natural products for ATL treatment.
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فهرسة مساهمة: Keywords: Arrabidaea brachypoda; leishmaniasis; pluronic F127
تواريخ الأحداث: Date Created: 20240224 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10891960
DOI: 10.3390/pharmaceutics16020252
PMID: 38399306
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics16020252