دورية أكاديمية
أعرض في EDS

Antioxidant and anti-inflammatory potentials of Ammodaucus leucotrichus Coss. & Durieu seeds' extracts: In vitro and in vivo studies.

التفاصيل البيبلوغرافية
العنوان: Antioxidant and anti-inflammatory potentials of Ammodaucus leucotrichus Coss. & Durieu seeds' extracts: In vitro and in vivo studies.
المؤلفون: Laroui H; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: laroui.haifa@gmail.com., Guemmaz T; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: thorayaguem@gmail.com., Zerargui F; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: fatimazerargui512@gmail.com., Saffidine K; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: saffidinekarima@gmail.com., Guenifi S; Department of Pathological Anatomy, University Hospital of Setif, Setif, 19000, Algeria. Electronic address: saraguenifi525@gmail.com., Arrar L; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: lekharrar@yahoo.fr., Khennouf S; Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Natural and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: khennouf_sed@yahoo.fr., Zengin G; Laboratory of Physiology and Biochemistry, Department of Biology, Science Faculty, Selcuk University, Konya, 42130, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr., Baghiani A; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, Setif 1 University, Setif, 19000, Algeria. Electronic address: baghianiab@hotmail.co.uk.
المصدر: Journal of ethnopharmacology [J Ethnopharmacol] 2024 May 23; Vol. 326, pp. 117964. Date of Electronic Publication: 2024 Feb 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Sequoia
Original Publication: Lausanne, Elsevier Sequoia.
مواضيع طبية MeSH: Antioxidants*/pharmacology , Antioxidants*/therapeutic use , Antioxidants*/chemistry , Xylenes* , Sulfonic Acids* , Benzothiazoles*, Humans ; Croton Oil ; Linoleic Acid ; Phytotherapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Carrageenan ; Acetic Acid/therapeutic use ; Inflammation ; Edema/chemically induced ; Edema/drug therapy ; Seeds ; Serum Albumin, Human ; Analgesics/pharmacology
مستخلص: Ethnopharmacological Relevance: Ammodaucus leucotrichus Coss. & Durieu (Apiaceae) is traditionally used in southern Algeria as a remedy against a wide range of disease due to its health-promoting properties.
Aim of the Study: To investigate anti-oxidant and anti-inflammatory potentials of plant methanolic extract and its fractions in vitro and in vivo.
Materials and Methods: Anti-radical activity was assessed in vitro using ABTS •+ , superoxide anion (O 2 •- ) and nitric oxide radical ( • NO). Lipid peroxidation inhibition was also investigated in the linoleic acid system. Enzyme inhibition assay was performed against α-amylase and α-glucosidase. The anti-inflammatory effect of extracts was screened in vitro through thermal induction of human serum albumin, and in vivo on a skin acute inflammation model induced by λ-carrageenan paw injection, xylene and croton oil topical application. Analgesic effect was evaluated by acetic acid-induced writhing test.
Results: The highest contents of polyphenols and flavonoids was recorded by the crude extract (77.14 ± 0.01 μg GAE/mg E and 19.59 ± 0.08 μg QE/mg E, respectively). Among the extracts, ethyl acetate extract showed a promising anti-radical activity of ABTS •+ , O 2 •- and • NO, in addition to a remarkable inhibition activity of the tested enzymes. Meanwhile, all extracts effectively protected linoleic acid against lipid peroxidation and human serum albumin structure in thermal condition even at low concentration (0.31 mg/ml). Oral administration of 200 mg/kg of crude extract successfully inhibited acetic acid induced nociception and reduced edema formation induced by xylene and carrageenan. However, a dose-dependent manner was observed to decrease ear edema by a microscopic examination in croton oil induced acute inflammation. Nitrite and malondialdehyde levels together with catalase activity were modulated in the presence of plant-derived bioactive compounds.
Conclusions: This study showed that Ammodaucus leucotrichus is potentially rich source of anti-oxidant and anti-inflammatory bioactive compounds.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Ammodaucus leucotrichus; Anti-inflammatory effect; Anti-oxidant activity; Enzyme inhibition; Polyphenols
المشرفين على المادة: 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid)
0 (Antioxidants)
0 (Xylenes)
8001-28-3 (Croton Oil)
9KJL21T0QJ (Linoleic Acid)
0 (Anti-Inflammatory Agents)
0 (Plant Extracts)
9000-07-1 (Carrageenan)
Q40Q9N063P (Acetic Acid)
ZIF514RVZR (Serum Albumin, Human)
0 (Analgesics)
0 (Sulfonic Acids)
0 (Benzothiazoles)
تواريخ الأحداث: Date Created: 20240224 Date Completed: 20240315 Latest Revision: 20240315
رمز التحديث: 20240315
DOI: 10.1016/j.jep.2024.117964
PMID: 38401663
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7573
DOI:10.1016/j.jep.2024.117964