دورية أكاديمية
Elevated levels of citrullinated fibrinogen in patients with cancer.
| العنوان: | Elevated levels of citrullinated fibrinogen in patients with cancer. |
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| المؤلفون: | Arfman T; Department of Molecular Hematology Sanquin Research and Landsteiner Laboratory Amsterdam The Netherlands., Zollet V; Department for BioMedical Research (DBMR) University of Bern Bern Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB) University of Bern Bern Switzerland., van Es N; Department of Vascular Medicine Amsterdam UMC location University of Amsterdam Amsterdam The Netherlands.; Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam The Netherlands., Bosch FTM; Department of Vascular Medicine Amsterdam UMC location University of Amsterdam Amsterdam The Netherlands., Nicolaes GAF; Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht The Netherlands., Sorvillo N; Department for BioMedical Research (DBMR) University of Bern Bern Switzerland., Voorberg J; Department of Molecular Hematology Sanquin Research and Landsteiner Laboratory Amsterdam The Netherlands.; Department of Experimental Vascular Medicine Academic Medical Centre Amsterdam University of Amsterdam Amsterdam The Netherlands. |
| المصدر: | EJHaem [EJHaem] 2024 Jan 26; Vol. 5 (1), pp. 136-140. Date of Electronic Publication: 2024 Jan 26 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101761942 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-6146 (Electronic) Linking ISSN: 26886146 NLM ISO Abbreviation: EJHaem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hoboken, New Jersey] : John Wiley & Sons, Inc., [2020]- |
| مستخلص: | Neutrophil released peptidyl arginine deiminase 4 (PAD4) converts arginine residues on plasma proteins into citrulline. Here, we developed an assay to quantify citrullinated fibrinogen. We employed a biotin-conjugated phenylglyoxal (biotin-phenylglyoxal (PG)) compound that selectively labels citrulline. Patient samples were derived from a multicenter prospective cohort study that aimed to identify cancer patients at high risk for venous thromboembolism (VTE). Our data show that cancer patients have higher (median 2-fold increased) citrullinated fibrinogen levels when compared to normal human plasma and a cohort of healthy donors. Our results show that citrullination of fibrinogen is a common posttranslational modification in patients with cancer. Competing Interests: None of the authors have conflict of interest to report. (© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: cancer; citrullination; coagulation; fibrinogen; thrombosis |
| تواريخ الأحداث: | Date Created: 20240226 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| مُعرف محوري في PubMed: | PMC10887244 |
| DOI: | 10.1002/jha2.825 |
| PMID: | 38406510 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2688-6146 |
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| DOI: | 10.1002/jha2.825 |