دورية أكاديمية
Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy.
| العنوان: | Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy. |
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| المؤلفون: | Johnson DA; College of Optometry, The Ohio State University, Columbus, OH, USA., Doble N; College of Optometry, The Ohio State University, Columbus, OH, USA.; Department of Ophthalmology and Vision Science, Havener Eye Institute, The Ohio State University, Columbus, OH, USA., Choi SS; College of Optometry, The Ohio State University, Columbus, OH, USA.; Department of Ophthalmology and Vision Science, Havener Eye Institute, The Ohio State University, Columbus, OH, USA. |
| المصدر: | Current eye research [Curr Eye Res] 2024 Jun; Vol. 49 (6), pp. 650-662. Date of Electronic Publication: 2024 Feb 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8104312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2202 (Electronic) Linking ISSN: 02713683 NLM ISO Abbreviation: Curr Eye Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : IRL Press, [c1981- |
| مواضيع طبية MeSH: | Tomography, Optical Coherence*/methods , Retinal Cone Photoreceptor Cells*/pathology , Retinal Vessels*/diagnostic imaging , Retinal Vessels*/pathology , Retinal Vessels*/physiopathology , Diabetic Retinopathy*/physiopathology , Diabetic Retinopathy*/diagnosis , Fluorescein Angiography*/methods, Humans ; Male ; Female ; Middle Aged ; Ophthalmoscopy ; Aged ; Fundus Oculi ; Adult ; Visual Acuity/physiology ; Macula Lutea/pathology |
| مستخلص: | Purpose: To characterize any differences in the vasculature and cone photoreceptor packing geometry (CPG) between subjects with diabetes without/no diabetic retinopathy (NDR) and healthy controls. Methods: Eight NDR and five controls were enrolled. Optical coherence tomography angiography (OCTA) taken at the macula was used to measure vessel density, vessel length density, and vessel density index (VDI) in three vascular plexuses, namely, the superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus (DCP). The choriocapillaris (CC) flow deficit (FD) was also measured. OCTA images were binarized and processed to extrapolate the parafovea and parafoveal quadrants and the OCTA indices mentioned above. The CC was processed with six different radii to quantify FD. Adaptive optics - scanning laser ophthalmoscopy images were acquired and processed to extract CPG indices, i.e., cone density (CD), cone-to-cone spacing (CS), linear dispersion index, heterogeneity packing index and percent of cells with six neighbors at 3.6° in the temporal retina. Results: In all eyes, statistically significant differences were found (i) in parafoveal FD across the six radii ( p < 0.001) and (ii) in the correlation between the parafoveal temporal quadrant (PTQ) DCP VDI and CS ( r = 0.606, p = 0.048). No other significant correlations were found. For OCTA or CPG indices, no significant differences were found between the cohorts in the parafovea or parafoveal quadrants. Conclusions: CS is the most sensitive CPG index for detecting alterations in the cone mosaic. The DCP and the cone photoreceptors are significantly correlated, indicating that alterations in the DCP can affect the cones. Future work elucidating the vascular alterations and neurodegeneration present in diabetic eyes should focus on the DCP and multiple CPG indices, not solely CD. Moreover, such alterations are highly localized, hence using larger regions e.g. parafovea versus smaller areas, such as the PTQ, will potentially mask significant correlations. |
| فهرسة مساهمة: | Keywords: Diabetes; adaptive optics scanning laser ophthalmoscopy; choriocapillaris; cone photoreceptors; optical coherence tomography angiography; retinal vasculature |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240522 Latest Revision: 20240528 |
| رمز التحديث: | 20240529 |
| DOI: | 10.1080/02713683.2024.2320787 |
| PMID: | 38407181 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1460-2202 |
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| DOI: | 10.1080/02713683.2024.2320787 |