دورية أكاديمية
One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy.
| العنوان: | One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy. |
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| المؤلفون: | Kanjanaruch C; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Bochantin KA; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Dávila Ruiz BJ; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Syring J; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Entzie Y; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., King L; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Borowicz PP; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Crouse MS; USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE 68933, USA., Caton JS; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Dahlen CR; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA., Ward AK; Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, Canada., Reynolds LP; Department of Animal Sciences and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA. |
| المصدر: | Journal of animal science [J Anim Sci] 2024 Jan 03; Vol. 102. |
| نوع المنشور: | Randomized Controlled Trial, Veterinary; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Animal Science Country of Publication: United States NLM ID: 8003002 Publication Model: Print Cited Medium: Internet ISSN: 1525-3163 (Electronic) Linking ISSN: 00218812 NLM ISO Abbreviation: J Anim Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Champaign, IL : American Society of Animal Science |
| مواضيع طبية MeSH: | Placenta* , Iron-Dextran Complex*, Female ; Pregnancy ; Animals ; Cattle ; Plant Breeding ; Methionine/pharmacology ; Racemethionine ; Carbon ; Choline/pharmacology ; Dietary Supplements ; Folic Acid/pharmacology ; Vitamin B 12/pharmacology ; Diet/veterinary |
| مستخلص: | We hypothesized that restricted maternal nutrition and supplementation of one-carbon metabolites (OCM; methionine, folate, choline, and vitamin B12) would affect placental vascular development during early pregnancy. A total of 43 cows were bred, and 32 heifers successfully became pregnant with female calves, leading to the formation of four treatment groups: CON - OCM (n = 8), CON + OCM (n = 7), RES - OCM (n = 9), and RES + OCM (n = 8). The experimental design was a 2 × 2 factorial, with main factors of dietary intake affecting average daily gain: control (CON; 0.6 kg/d ADG) and restricted (RES; -0.23 kg/d ADG); and OCM supplementation (+OCM) in which the heifers were supplemented with rumen-protected methionine (7.4 g/d) and choline (44.4 g/d) and received weekly injections of 320 mg of folate and 20 mg of vitamin B12, or received no supplementation (-OCM; corn carrier and saline injections). Heifers were individually fed and randomly assigned to treatment at breeding (day 0). Placentomes were collected on day 63 of gestation (0.225 of gestation). Fluorescent staining with CD31 and CD34 combined with image analysis was used to determine the vascularity of the placenta. Images were analyzed for capillary area density (CAD) and capillary number density (CND). Areas evaluated included fetal placental cotyledon (COT), maternal placental caruncle (CAR), whole placentome (CAR + COT), intercotyledonary fetal membranes (ICOT, or chorioallantois), intercaruncular endometrium (ICAR), and endometrial glands (EG). Data were analyzed with the GLM procedure of SAS, with heifer as the experimental unit and significance at P ≤ 0.05 and a tendency at P > 0.05 and P < 0.10. Though no gain × OCM interactions existed (P ≥ 0.10), OCM supplementation increased (P = 0.01) CAD of EG, whereas nutrient restriction tended (P < 0.10) to increase CAD of ICOT and CND of COT. Additionally, there was a gain × OCM interaction (P < 0.05) for CAD within the placentome and ICAR, such that RES reduced and supplementation of RES with OCM restored CAD. These results indicate that maternal rate of gain and OCM supplementation affected placental vascularization (capillary area and number density), which could affect placental function and thus the efficiency of nutrient transfer to the fetus during early gestation. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
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| فهرسة مساهمة: | Keywords: beef cattle; maternal nutrient restriction; one-carbon metabolites; placental vasculature Local Abstract: [plain-language-summary] In cow–calf production, periods of poor forage availability or quality can result in nutrient restriction during pregnancy. Previous studies have shown that even moderate maternal feed restriction during pregnancy, including very early in pregnancy, has profound effects on fetal and placental development, potentially having lasting impacts on calf growth and body composition later in life. One-carbon metabolites (OCM) in the diet are biomolecules required for methylation reactions and participate in the regulation of gene expression. Our objective was to evaluate the effects of nutrient restriction and OCM supplementation (specifically methionine, choline, folate, and vitamin B12) on placental vascular development during early pregnancy. Proper placental vascular development is necessary for healthy pregnancy outcomes, reflected by normal birth weight and healthy offspring. Our results indicated that maternal rate of gain and OCM supplementation affect placental vascularization, which could affect placental function and thereby fetal development throughout gestation. In the context of beef cattle production, our study sheds light on strategies that could enhance placental vascular development during early pregnancy. However, it is essential to recognize the nuances in our data, highlighting the need for further research to fully comprehend these intricate processes. |
| المشرفين على المادة: | 9004-66-4 (Iron-Dextran Complex) AE28F7PNPL (Methionine) 73JWT2K6T3 (Racemethionine) 7440-44-0 (Carbon) N91BDP6H0X (Choline) 935E97BOY8 (Folic Acid) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240304 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| مُعرف محوري في PubMed: | PMC10907004 |
| DOI: | 10.1093/jas/skae044 |
| PMID: | 38407272 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-3163 |
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| DOI: | 10.1093/jas/skae044 |