دورية أكاديمية
Morphological Biomarkers Related to Visual Acuity in Patients With Radiation Retinopathy Treated With Intravitreal Ranibizumab.
| العنوان: | Morphological Biomarkers Related to Visual Acuity in Patients With Radiation Retinopathy Treated With Intravitreal Ranibizumab. |
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| المؤلفون: | Corona ST, Ali OI, Yu HJ, Schefler AC |
| مؤلفون مشاركون: | RRR Study Group |
| المصدر: | Ophthalmic surgery, lasers & imaging retina [Ophthalmic Surg Lasers Imaging Retina] 2024 May; Vol. 55 (5), pp. 255-262. Date of Electronic Publication: 2024 Mar 01. |
| نوع المنشور: | Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Healio.com Country of Publication: United States NLM ID: 101599215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2325-8179 (Electronic) Linking ISSN: 23258160 NLM ISO Abbreviation: Ophthalmic Surg Lasers Imaging Retina Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013-> : Thorofare, NJ : Healio.com Original Publication: Thorofare, NJ : Slack Incorporated [2013- ] |
| مواضيع طبية MeSH: | Angiogenesis Inhibitors*/administration & dosage , Angiogenesis Inhibitors*/therapeutic use , Biomarkers* , Intravitreal Injections* , Radiation Injuries*/diagnosis , Radiation Injuries*/drug therapy , Radiation Injuries*/etiology , Ranibizumab*/administration & dosage , Retinal Diseases*/diagnosis , Retinal Diseases*/physiopathology , Retinal Diseases*/drug therapy , Retinal Diseases*/etiology , Tomography, Optical Coherence*/methods , Visual Acuity*, Aged ; Female ; Humans ; Male ; Middle Aged ; Retina/radiation effects ; Retina/pathology ; Retina/diagnostic imaging ; Vascular Endothelial Growth Factor A/antagonists & inhibitors |
| مستخلص: | Background and Objective: Our objective was to monitor variables via spectral-domain optical coherence tomography (SD-OCT) and identify the most relevant biomarkers related to best-corrected visual acuity (BCVA) in radiation retinopathy (RR). Patients and Methods: A post-hoc analysis of the two-year Ranibizumab for Radiation Retinopathy (RRR) trial analyzed vision and OCT parameters including intraretinal fluid, ellipsoid zone (EZ) disruption, retinal pigment epithelium atrophy, hard exudates, retinal hemorrhage, retinal neovascularization, and subfoveal fluid. BCVA and SD-OCT parameters were evaluated by univariate analysis and a mixed-effects model. Results: Forty eyes from the RRR trial were included. Intraretinal cyst vertical size (week 24: P = 0.032; week 48: P = 0.021), neovascularization (week 48: P = 0.028; week 72: P = 0.025), and EZ disruption (week 72: P = 0.029; week 104: P = 0.019) were the clinical parameters most relevant to BCVA by univariate analysis in at least two time points. The mixed-effects model confirmed the relevance of intraretinal cyst vertical size ( P = 0.001) and neovascularization ( P = 0.001) but not EZ disruption ( P = 0.119) over the course of the study. Conclusions: This study characterizes the course of visual loss in RR by identifying intraretinal cyst vertical size, neovascularization, and EZ disruption as biomarkers of poor BCVA over a span of two years. Larger multicenter studies are needed to confirm these findings. [ Ophthalmic Surg Lasers Imaging Retina 2024;55:255-262.] . |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Biomarkers) ZL1R02VT79 (Ranibizumab) 0 (Vascular Endothelial Growth Factor A) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240516 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| DOI: | 10.3928/23258160-20240129-01 |
| PMID: | 38408221 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2325-8179 |
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| DOI: | 10.3928/23258160-20240129-01 |