دورية أكاديمية
Natural compounds mitigate mycotoxins-induced neurotoxicity by modulating oxidative tonus: in vitro and in vivo insights - a review.
| العنوان: | Natural compounds mitigate mycotoxins-induced neurotoxicity by modulating oxidative tonus: in vitro and in vivo insights - a review. |
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| المؤلفون: | Del Fabbro L; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos, Universidade Federal de Santa Maria, Santa Maria, Brasil., Sari MHM; Departamento de Análises Clínicas, Universidade Federal do Paraná, Curitiba, Brasil., Ferreira LM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, Brasil., Furian AF; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos e Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, Brasil. |
| المصدر: | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2024 Apr; Vol. 41 (4), pp. 438-459. Date of Electronic Publication: 2024 Feb 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101485040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-0057 (Electronic) Linking ISSN: 19440057 NLM ISO Abbreviation: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Abingdon, Oxon ; Philadelphia, PA : Taylor & Francis, 2008- |
| مواضيع طبية MeSH: | Mycotoxins*/toxicity , Mycotoxins*/analysis , Ochratoxins*/analysis , Zearalenone*/analysis, Animals ; Food Contamination/analysis ; Animal Feed/analysis ; Oxidative Stress |
| مستخلص: | This review explores the repercussions of mycotoxin contamination in food and feed, emphasising potential threats to agriculture, animal husbandry and public health. The primary objective is to make a comprehensive assessment of the neurotoxic consequences of mycotoxin exposure, an aspect less explored in current literature. Emphasis is placed on prominent mycotoxins, including aflatoxins, fumonisins, zearalenone (ZEA) and ochratoxins, known for inducing acute and chronic diseases such as liver damage, genetic mutation and cancer. To elucidate the effects, animal studies were conducted, revealing an association between mycotoxin exposure and neurological damage. This encompasses impairments in learning and memory, motor alterations, anxiety and depression. The underlying mechanisms involve oxidative stress, disrupting the balance between reactive oxygen species (ROS) and antioxidant capacity. This oxidative stress is linked to neuronal damage, brain inflammation, neurochemical imbalance, and subsequent behavioural changes. The review underscores the need for preventive measures against mycotoxin exposure. While complete avoidance is ideal, exploration into the potential use of antioxidants as a viable solution is discussed, given the widespread contamination of many food products. Specifically, the protective role of natural compounds, such as polyphenols, is highlighted, showcasing their efficacy in mitigating mycotoxicosis in the central nervous system (CNS), as evidenced by findings in various animal models. In summary, countering mycotoxin-induced neurotoxicity requires a multifaceted approach. The identified natural compounds show promise, but their practical use hinges on factors like bioavailability, toxicity and understanding their mechanisms of action. Extensive research is crucial, considering the diverse responses to different mycotoxins and neurological conditions. Successful implementation relies on factors such as the specific mycotoxin(s) involved and achievable effective concentrations. Further research and clinical trials are imperative to establish the safety and efficacy of these compounds in practical applications. |
| فهرسة مساهمة: | Keywords: Aflatoxin; antioxidant; neuroinflammation; oxidative stress |
| المشرفين على المادة: | 0 (Mycotoxins) 0 (Ochratoxins) 5W827M159J (Zearalenone) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240327 Latest Revision: 20240327 |
| رمز التحديث: | 20240327 |
| DOI: | 10.1080/19440049.2024.2316750 |
| PMID: | 38408272 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher 
Full Text Finder | تدمد: | 1944-0057 |
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| DOI: | 10.1080/19440049.2024.2316750 |