دورية أكاديمية
Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation.
| العنوان: | Biodistribution of radiolabeled alpha-amanitin in mice: An Investigation. |
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| المؤلفون: | Durkan K; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey. Electronic address: kubra.durkan@ege.edu.tr., Ichedef C; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey., Baris E; Department of Pharmacology, Faculty of Medicine, Izmir University of Economics, Izmir, Turkey., Arici MA; Department of Medical Pharmacology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Apr; Vol. 241, pp. 107661. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Alpha-Amanitin*/toxicity , Mushroom Poisoning*, Animals ; Mice ; Tissue Distribution ; Iodine Radioisotopes ; Amanita |
| مستخلص: | Mushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with Iodine-131. Mice were injected with a toxic dose (1.4 mg/kg) of α-AMA labeled with Iodine-131. The mice were sacrificed at the 1st, 2nd, 4th, 8th, 24th, and 48th hours under anesthesia. The organs of the mice were removed, and their biodistribution was assessed in all experiments. The percent injected dose per gram (ID/g %) value for kidney, liver, lung, and heart tissues at 1st hour were 1.59 ± 0.07, 1.25 ± 0.33, 3.67 ± 0.80 and 1.07 ± 0.01 respectively. This study provides insights into the potential long-term effects of α-AMA accumulation in specific organs. Additionally, this study has generated essential data that can be used to demonstrate the impact of antidotes on the biological distribution of α-AMA in future toxicity models. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alpha-amanitin; Amanita phalloides; I-131; In vivo biodistribution; Toxicity |
| المشرفين على المادة: | 0 (Alpha-Amanitin) 0 (Iodine-131) 0 (Iodine Radioisotopes) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240329 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| DOI: | 10.1016/j.toxicon.2024.107661 |
| PMID: | 38408526 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2024.107661 |