دورية أكاديمية
A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models.
| العنوان: | A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models. |
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| المؤلفون: | Stewart HL; Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA., Gilbert D; Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA., Stefanovski D; Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA., Garman Z; Departments of Biomedical Engineering and Chemistry, Boston University, Boston MA 02215, USA., Albro MB; Department of Mechanical Engineering, Boston University, Boston MA 02215, USA., Bais M; Boston University, Henry M. Goldman School of Dental Medicine, Boston MA 02118, USA., Grinstaff MW; Departments of Biomedical Engineering and Chemistry, Boston University, Boston MA 02215, USA., Snyder BD; Department of Orthopaedic Surgery, Boston Children's Hospital Boston, MA 02215, USA., Schaer TP; Department of Clinical Studies New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA. Electronic address: tpschaer@vet.upenn.edu. |
| المصدر: | Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2024 May; Vol. 32 (5), pp. 501-513. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : W.B. Saunders For The Osteoarthritis Research Society Original Publication: London : Published for the Society by Baillère Tindall, c1993- |
| مواضيع طبية MeSH: | Osteoarthritis*/veterinary, Female ; Male ; Swine ; Animals ; Sheep ; Horses ; Dogs ; Disease Models, Animal ; Goats ; Bibliometrics ; Growth Plate |
| مستخلص: | Objective: The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding. Method: A scoping literature review of PubMed, Web of Science, EMBASE, and SCOPUS was performed for studies evaluating the effect of sex and age in experimental studies and clinical trials utilizing preclinical large animal models of OA. Results: A total of 9727 papers were identified in large animal (dog, pig, sheep, goat, horse) models for preclinical OA research, of which 238 ex vivo and/or in vivo studies disclosed model type, animal species, sex, and skeletal age sufficient to analyze their effect on outcomes. Dogs, followed by pigs, sheep, and horses, were the most commonly used models. A paucity of preclinical studies evaluated the effect of sex and age in large animal models of naturally occurring or experimentally induced OA: 26 total studies reported some kind of analysis of the effects of sex or age, with 4 studies discussing the effects of sex only, 11 studies discussing the effects of age only, and 11 studies analyzing both the effects of age and sex. Conclusion: Fundamental to translational research, OARSI is uniquely positioned to develop recommendations for conducting preclinical studies using large animal models of OA that consider biological mechanisms linked to sex chromosomes, skeletal age, castration, and gonadal hormones affecting OA pathophysiology and treatment response. Competing Interests: Declaration of Competing Interest The authors have no conflicts to declare. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Castration; Estrous cycle; Osteoarthritis; Preclinical model; Sex; Skeletal maturity |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240422 Latest Revision: 20240422 |
| رمز التحديث: | 20240422 |
| DOI: | 10.1016/j.joca.2024.02.009 |
| PMID: | 38408635 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1522-9653 |
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| DOI: | 10.1016/j.joca.2024.02.009 |