دورية أكاديمية
Human biomonitoring of dioxins, furans, and non-ortho dioxin-like polychlorinated biphenyls (PCBs) in blood plasma from Old Crow, Yukon, Canada (2019).
| العنوان: | Human biomonitoring of dioxins, furans, and non-ortho dioxin-like polychlorinated biphenyls (PCBs) in blood plasma from Old Crow, Yukon, Canada (2019). |
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| المؤلفون: | Simpson AK; School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Electronic address: aksimpson@uwaterloo.ca., Drysdale M; School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Electronic address: mebdrysdale@uwaterloo.ca., Gamberg M; Gamberg Consulting, Whitehorse, Yukon Y1A 6N5, Canada., Froese K; GatePost Risk Analysis, Red Deer, Alberta T4R 0A9, Canada. Electronic address: ken@gatepost.ca., Brammer J; Vuntut Gwitchin Government, Old Crow, Yukon Y0B 1N0, Canada. Electronic address: jeremy.brammer@vgfn.net., Dumas P; Centre de Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec G1V 5B3, Canada. Electronic address: pierre.dumas@inspq.qc.ca., Ratelle M; École de santé publique, Université de Montréal, 7101, avenue du Parc, Montréal, Québec H3N 1X9, Canada. Electronic address: Mylene.Ratelle@umontreal.ca., Skinner K; School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Electronic address: kskinner@uwaterloo.ca., Laird BD; School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Electronic address: brian.laird@uwaterloo.ca. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2024 May 01; Vol. 923, pp. 171222. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Dioxins*/analysis , Polychlorinated Biphenyls*/analysis , Crows* , Polychlorinated Dibenzodioxins*, Animals ; Humans ; Yukon Territory ; Furans/toxicity ; Biological Monitoring ; Canada ; Plasma/chemistry |
| مستخلص: | Dioxins, furans, and dioxin-like polychlorinated biphenyls (PCBs) are a group of persistent and toxic chemicals that are known to have human health effects at low levels. These chemicals have been produced for commercial use (PCBs) or unintentionally as by-products of industry or natural processes (PCBs, dioxins, and furans). Additionally, dioxin-like PCBs were formerly used in electrical applications before being banned internationally (2004). These chemicals are widely dispersed in the environment as they can contaminate air and travel hundreds to thousands of kilometers before depositing on land or water, thereafter, potentially entering food chains. Community concerns surrounding the safety of traditional foods prompted a human biomonitoring project in Old Crow, Yukon Territory (YT), Canada (2019). Through collaborative community engagement, dioxins and like compounds were identified as a priority for exposure assessment from biobanked samples. In 2022, biobanked plasma samples (n = 54) collected in Old Crow were used to measure exposures to seven dioxins, ten furans, and four dioxin-like PCBs. 1,2,3,6,7,8-HxCDD, 1,2,3,7,8,9-HxCDD, 1,2,3,4,6,7,8-HpCDD, OCDD, 2,3,4,7,8-PeCDF, 1,2,3,6,7,8-HxCDF, PCB 126, and PCB 169 were detected in at least 50 % of samples. Among these analytes, the only congener at elevated levels was PCB 169, which was approximately ∼2-fold higher than the general population of Canada. No significant sex-based or body mass index (BMI) differences in biomarker concentrations were observed. Generally, the concentrations of the detected congeners increased with age, except for 1,2,3,4,6,7,8-HpCDD. For the first time, this research measures dioxin and like-compound exposures in Old Crow, advancing the information available on chemical exposures in the Arctic. Further research could be directed towards the investigation of PCB 169 exposure sources and temporal monitoring of exposures and determinants. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Arctic; Contaminant; Exposure; Indigenous; Persistent organic pollutant; Traditional food |
| المشرفين على المادة: | B94L7A4G3D (1,2,3,6,7,8-hexachlorodibenzodioxin) 0 (Dioxins) MM6333103R (1,2,3,4,6,7,8-heptachlorodibenzodioxin) T2P1WH546D (3,4,5,3',4',5'-hexachlorobiphenyl) DFC2HB4I0K (Polychlorinated Biphenyls) 0 (Furans) 0 (Polychlorinated Dibenzodioxins) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240327 Latest Revision: 20240327 |
| رمز التحديث: | 20240327 |
| DOI: | 10.1016/j.scitotenv.2024.171222 |
| PMID: | 38408666 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
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| DOI: | 10.1016/j.scitotenv.2024.171222 |