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Synthetic Peptides with Genetic-Codon-Tailored Affinity for Assembling Tetraspanin CD81 at Cell Interfaces and Inhibiting Cancer Metastasis.

التفاصيل البيبلوغرافية
العنوان: Synthetic Peptides with Genetic-Codon-Tailored Affinity for Assembling Tetraspanin CD81 at Cell Interfaces and Inhibiting Cancer Metastasis.
المؤلفون: Xu K; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Gao H; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Li Y; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Jin Y; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Zhao R; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Huang Y; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 May 13; Vol. 63 (20), pp. e202400129. Date of Electronic Publication: 2024 Apr 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-
مواضيع طبية MeSH: Peptides*/chemistry , Peptides*/metabolism , Peptides*/pharmacology , Tetraspanin 28*/metabolism , Tetraspanin 28*/chemistry, Humans ; Neoplasm Metastasis ; Cell Movement/drug effects ; Cell Line, Tumor ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism
مستخلص: Probing biomolecular interactions at cellular interfaces is crucial for understanding and interfering with life processes. Although affinity binders with site specificity for membrane proteins are unparalleled molecular tools, a high demand remains for novel multi-functional ligands. In this study, a synthetic peptide (APQQ) with tight and specific binding to the untargeted extracellular loop of CD81 evolved from a genetically encoded peptide pool. With tailored affinity, APQQ flexibly accesses, site-specifically binds, and forms a complex with CD81, enabling in-situ tracking of the dynamics and activity of this protein in living cells, which has rarely been explored because of the lack of ligands. Furthermore, APQQ triggers the relocalization of CD81 from diffuse to densely clustered at cell junctions and modulates the interplay of membrane proteins at cellular interfaces. Motivated by these, efficient suppression of cancer cell migration, and inhibition of breast cancer metastasis were achieved in vivo.
(© 2024 Wiley-VCH GmbH.)
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معلومات مُعتمدة: 22122411 National Natural Science Foundation of China; 22374152 National Natural Science Foundation of China; 21974143 National Natural Science Foundation of China; 22174145 National Natural Science Foundation of China; Chinese Academy of Sciences
فهرسة مساهمة: Keywords: Antitumor agents; Cell migration; Imaging; Peptides; Tetraspanin
المشرفين على المادة: 0 (Peptides)
0 (Tetraspanin 28)
0 (CD81 protein, human)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20240227 Date Completed: 20240506 Latest Revision: 20240730
رمز التحديث: 20240730
DOI: 10.1002/anie.202400129
PMID: 38409630
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-3773
DOI:10.1002/anie.202400129